Ravichandran Sugan, Petchiappan Velammal, Rajangam Tolstoy, Vengudusamy Sivakumar, Prabu Vadivelmurugan Nagasubramani Naga
Department of General Medicine.
Department of Rheumatology, PSG Institute of Medical Sciences, Coimbatore, Tamilnadu, India.
Mediterr J Rheumatol. 2024 Jan 25;35(3):432-437. doi: 10.31138/mjr.210223.lfi. eCollection 2024 Sep.
Extra-articular manifestations especially haematological abnormalities are common in Rheumatoid arthritis (RA). The aim is to study the haematological parameters and its correlation with disease severity and gender.
A cross-sectional study was conducted at a tertiary centre among 50 RA patients who attended the Rheumatology or General Medicine OPD from January 2020 to June 2021. The number of swollen joints, tender joints, the patient's global assessment, rheumatoid factor, and complete blood counts were recorded. Disease Activity Score (DAS-28) was calculated from these variables and data was analysed using SPSS version 29 with p<0.05 considered as statistically significant.
Of the study subjects, forty (80%) were females; thirty (60%) belonged to the age group 41-50 years. Median age was 42.4(18, 50) years. 79 % (19 out of 24) of subjects with normal haemoglobin had moderate disease activity on DAS 28 score and 50% (13/26) of participants with low haemoglobin levels had high disease activity. Simple linear regression analysis showed low haemoglobin is inversely associated with DAS 28 score (R2 = 0.407, F= 32.888, p < 0.001). Compared to females, males had a higher haemoglobin level which was statistically significant. Female patients had statistically significant higher DAS 28 scores than males (p = 0.016).
Low haemoglobin levels are associated with high disease activity in RA patients and males had less severe disease than females.
关节外表现尤其是血液学异常在类风湿关节炎（RA）中很常见。本研究旨在探讨血液学参数及其与疾病严重程度和性别的相关性。
在一家三级医疗中心进行了一项横断面研究，研究对象为2020年1月至2021年6月期间到风湿科或普通内科门诊就诊的50例RA患者。记录肿胀关节数、压痛关节数、患者整体评估、类风湿因子及全血细胞计数。根据这些变量计算疾病活动评分（DAS-28），并使用SPSS 29版软件进行数据分析，以p<0.05为差异有统计学意义。
研究对象中，40例（80%）为女性；30例（60%）年龄在41-50岁之间。中位年龄为42.4（18,50）岁。血红蛋白正常的患者中，79%（24例中的19例）DAS 28评分显示疾病活动度为中度，血红蛋白水平低的参与者中，50%（26例中的13例）疾病活动度高。简单线性回归分析显示，低血红蛋白与DAS 28评分呈负相关（R2 = 0.407，F = 32.888，p < 0.001）。与女性相比，男性血红蛋白水平较高，差异有统计学意义。女性患者的DAS 28评分显著高于男性（p = 0.016）。
RA患者血红蛋白水平低与疾病活动度高相关，男性疾病严重程度低于女性。
