Host RNA Metabolism Group, Institute for Molecular Infection Biology (IMIB), University of Würzburg, Würzburg, Germany.
Functional Genomics and RNA-based Therapeutics Group, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal.
Trends Microbiol. 2019 Mar;27(3):206-218. doi: 10.1016/j.tim.2018.10.011. Epub 2018 Nov 23.
MicroRNAs are a class of small noncoding RNAs that act as major post-transcriptional regulators of gene expression. They are currently recognized for their important role in the intricate interaction between host and bacterial pathogens, either as part of the host immune response to neutralize infection, or as a molecular strategy employed by bacteria to hijack host pathways for their own benefit. Here, we summarize recent advances on the function of miRNAs during infection of mammalian hosts by bacterial pathogens, highlighting key cellular pathways. In addition, we discuss emerging themes in this field, including the participation of miRNAs in host-microbiota crosstalk and cell-to-cell communication.
微小 RNA 是一类小的非编码 RNA，作为基因表达的主要转录后调控因子。目前，它们在宿主与细菌病原体之间复杂的相互作用中起着重要作用，要么作为宿主免疫反应的一部分来中和感染，要么作为细菌劫持宿主途径为自身利益服务的分子策略。在这里，我们总结了 miRNA 在细菌病原体感染哺乳动物宿主过程中的功能的最新进展，强调了关键的细胞途径。此外，我们还讨论了该领域的新兴主题，包括 miRNA 参与宿主-微生物群相互作用和细胞间通讯。
