Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Department of Biological Sciences, Florida State University, USA.
Arch Razi Inst. 2023 Dec 30;78(6):1668-1679. doi: 10.32592/ARI.2023.78.6.1668. eCollection 2023 Dec.
The genus is a widespread pathogen that includes more than 30 Gram-negative species, many of which are opportunistic bacteria. Aeromonas species are naturally distributed in various aquatic sources. Infectious processes in marine animals such as fish usually develop under stressful conditions, and when their immune systems are weakened. MicroRNAs (miRNAs/miRs) are short, non-coding RNAs that post-transcriptionally regulate gene expression. Their diverse biological functions, such as influencing cell development, proliferation, differentiation, tumorigenesis, metabolism, and apoptosis have been studied in various animals. Fish is the most important source of aquatic nutrients throughout the world, and its market is constantly growing. Overpopulation in aquaculture brings infectious diseases that threaten the development of aquaculture around the world. There is extensive evidence that microRNAs are involved in modulating infectious processes and regulating the inflammatory response to major bacterial fish infections, including . Here, we review the current literature on the fish microRNA repertoire and outline the physiological roles assigned to microRNAs to provide a foundation for future research during infection. Understanding the interaction between microRNAs and may provide clues to a remarkable strategy for preventing infections in fish.
属是一种广泛存在的病原体，包括 30 多种革兰氏阴性菌，其中许多是机会性细菌。气单胞菌属自然分布于各种水生源。海洋动物（如鱼类）的感染过程通常在应激条件下和免疫系统减弱时发生。微小 RNA（miRNAs/miRs）是短的非编码 RNA，可在后转录水平上调节基因表达。它们在各种动物中的多种生物学功能，如影响细胞发育、增殖、分化、肿瘤发生、代谢和细胞凋亡等，已被广泛研究。鱼类是全世界水生营养物的最重要来源，其市场不断增长。水产养殖过度繁殖带来的传染病威胁着全球水产养殖业的发展。有广泛的证据表明，微小 RNA 参与调节感染过程，并调节对主要细菌性鱼类感染的炎症反应，包括 。在这里，我们回顾了鱼类 microRNA 组的现有文献，并概述了分配给 microRNA 的生理作用，为 感染期间的未来研究提供了基础。了解 microRNAs 与 的相互作用可能为预防鱼类 感染提供一个显著的策略提供线索。
