序贯分离株的比较基因组学和治疗过程中棘白菌素耐药性的快速获得。
Comparative Genomics of Serial Isolates and the Rapid Acquisition of Echinocandin Resistance during Therapy.
机构信息
National Reference Center for Invasive Mycoses, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, Jena, Germany.
Systems Biology and Bioinformatics, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, Jena, Germany.
出版信息
Antimicrob Agents Chemother. 2019 Jan 29;63(2). doi: 10.1128/AAC.01628-18. Print 2019 Feb.
Abstract
The opportunistic pathogen shows a concerning increase in drug resistance. Here, we present the analysis of two serial bloodstream isolates, obtained 12 days apart. Both isolates show pan-azole resistance and echinocandin resistance was acquired during the sampling interval. Genome sequencing identified nine nonsynonymous SNVs between the strains, including a S663P substitution in FKS2 and previously undescribed SNVs in and , offering insight into how acquires drug resistance and adapts to a human host.
摘要
机会性病原体显示出令人担忧的耐药性增加。在这里，我们呈现了相隔 12 天获得的两个连续血流分离株的分析。两个分离株均显示出泛唑耐药性，并且在采样间隔期间获得了棘白菌素耐药性。基因组测序在菌株之间鉴定了九个非同义 SNV，包括 FKS2 中的 S663P 取代以及 和 中的以前未描述的 SNV，为了解 如何获得耐药性并适应人类宿主提供了线索。
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