Laboratory for Continuum Robotics, Leibniz Universität Hannover, Hanover, Germany.
International Neuroscience Institute, Image Guided Neurosurgical Therapy, Hanover, Germany.
Int J Comput Assist Radiol Surg. 2019 Feb;14(2):335-344. doi: 10.1007/s11548-018-1890-8. Epub 2018 Nov 27.
Laser-induced thermotherapy in the brain is a minimally invasive procedure to denature tumor tissue. However, irregularly shaped brain tumors cannot be treated using existing commercial systems. Thus, we present a new concept for laser-induced thermotherapy using a concentric tube robotic system. The planning procedure is complex and consists of the optimal distribution of thermal laser ablations within a volume as well as design and configuration parameter optimization of the concentric tube robot.
We propose a novel computer-assisted planning procedure that decomposes the problem into task- and robot-specific planning and uses a multi-objective particle swarm optimization algorithm with variable length.
The algorithm determines a Pareto-front of optimal ablation distributions for three patient datasets. It considers multiple objectives and determines optimal robot parameters for multiple trajectories to access the tumor volume.
We prove the effectiveness of our planning procedure to enable the treatment of irregularly shaped brain tumors. Multiple trajectories further increase the applicability of the procedure.
激光诱导热疗是一种用于使肿瘤组织变性的微创方法。然而,现有的商业系统无法治疗形状不规则的脑肿瘤。因此,我们提出了一种使用同心管机器人系统进行激光诱导热疗的新概念。规划过程非常复杂,包括在体积内最佳分配热激光消融以及同心管机器人的设计和配置参数优化。
我们提出了一种新的计算机辅助规划程序,将问题分解为任务和机器人特定的规划,并使用具有可变长度的多目标粒子群优化算法。
该算法为三个患者数据集确定了最优消融分布的 Pareto 前沿。它考虑了多个目标,并为多条轨迹确定了最佳机器人参数,以进入肿瘤体积。
我们证明了我们的规划程序能够有效治疗形状不规则的脑肿瘤。多条轨迹进一步提高了该程序的适用性。