University of Bordeaux, Bordeaux, France/Inserm U1215, Neurocentre Magendie, Bordeaux, France.
CHU Pellegrin, CHU de Bordeaux, Bordeaux, France.
Mult Scler. 2020 Feb;26(2):188-200. doi: 10.1177/1352458518813108. Epub 2018 Nov 27.
There is a lack of longitudinal studies exploring the topological organization of functional brain networks at the early stages of multiple sclerosis (MS).
This study aims to assess potential brain functional reorganization at rest in patients with CIS (PwCIS) after 1 year of evolution and to characterize the dynamics of functional brain networks at the early stage of the disease.
We prospectively included 41 PwCIS and 19 matched healthy controls (HCs). They were scanned at baseline and after 1 year. Using graph theory, topological metrics were calculated for each region. Hub disruption index was computed for each metric.
Hub disruption indexes of degree and betweenness centrality were negative at baseline in patients ( < 0.05), suggesting brain reorganization. After 1 year, hub disruption indexes for degree and betweenness centrality were still negative ( < 0.00001), but such reorganization appeared more pronounced than at baseline. Different brain regions were driving these alterations. No global efficiency differences were observed between PwCIS and HCs either at baseline or at 1 year.
Dynamic changes in functional brain networks appear at the early stages of MS and are associated with the maintenance of normal global efficiency in the brain, suggesting a compensatory effect.
缺乏探索多发性硬化症（MS）早期阶段功能脑网络拓扑组织的纵向研究。
本研究旨在评估 CIS 患者（PwCIS）在 1 年演变后的静息状态下潜在的大脑功能重组，并描述疾病早期功能脑网络的动态变化。
我们前瞻性地纳入了 41 名 CIS 患者和 19 名匹配的健康对照组（HCs）。他们在基线和 1 年后进行了扫描。使用图论，计算了每个区域的拓扑度量。计算了每个度量的枢纽破坏指数。
患者在基线时的度和介数中心性枢纽破坏指数为负值（<0.05），表明存在大脑重组。1 年后，度和介数中心性的枢纽破坏指数仍然为负值（<0.00001），但这种重组比基线时更为明显。不同的大脑区域驱动了这些改变。在基线或 1 年后，PwCIS 和 HCs 之间没有观察到全局效率的差异。
功能脑网络的动态变化在 MS 的早期阶段出现，与大脑中正常全局效率的维持有关，提示存在代偿效应。
