Institute of Physical Science and Information Technology, Anhui University, Hefei, 230601, Anhui, China.
School of Electrical and Information Engineering, Anhui University of Technology, Ma'anshan, 243032, Anhui, China.
BMC Bioinformatics. 2018 Nov 27;19(1):455. doi: 10.1186/s12859-018-2493-7.
Protein-protein interactions (PPIs) play important roles in biological functions. Studies of the effects of mutants on protein interactions can provide further understanding of PPIs. Currently, many databases collect experimental mutants to assess protein interactions, but most of these databases are old and have not been updated for several years.
To address this issue, we manually curated a kinetic and thermodynamic database of mutant protein interactions (dbMPIKT) that is freely accessible at our website. This database contains 5291 mutants in protein interactions collected from previous databases and the literature published within the last three years. Furthermore, some data analysis, such as mutation number, mutation type, protein pair source and network map construction, can be performed online.
Our work can promote the study on PPIs, and novel information can be mined from the new database. Our database is available in http://DeepLearner.ahu.edu.cn/web/dbMPIKT/ for use by all, including both academics and non-academics.
蛋白质-蛋白质相互作用（PPIs）在生物功能中发挥着重要作用。研究突变体对蛋白质相互作用的影响可以进一步了解 PPIs。目前，许多数据库收集实验突变体来评估蛋白质相互作用，但这些数据库大多比较陈旧，已经有好几年没有更新了。
为了解决这个问题，我们手动整理了一个突变体蛋白质相互作用的动力学和热力学数据库（dbMPIKT），该数据库可在我们的网站上免费访问。该数据库包含了从以前的数据库和过去三年发表的文献中收集的 5291 个蛋白质相互作用突变体。此外，还可以在线进行一些数据分析，如突变数量、突变类型、蛋白质对来源和网络图构建。
我们的工作可以促进对 PPIs 的研究，并且可以从新数据库中挖掘新的信息。我们的数据库可在 http://DeepLearner.ahu.edu.cn/web/dbMPIKT/ 上供所有人使用，包括学术界和非学术界人士。
