"Horia Hulubei" National Institute for Physics and Nuclear Engineering, Extreme Light Infrastructure - Nuclear Physics ELI-NP, 30 Reactorului Street, RO-077125, Bucharest-Magurele, Romania.
"Horia Hulubei" National Institute for Physics and Nuclear Engineering, Extreme Light Infrastructure - Nuclear Physics ELI-NP, 30 Reactorului Street, RO-077125, Bucharest-Magurele, Romania.
Life Sci Space Res (Amst). 2018 Nov;19:68-75. doi: 10.1016/j.lssr.2018.10.003. Epub 2018 Oct 20.
One of the specific properties of laser-driven radiation is a broadband energy spectrum, which is also a feature of the space radiation fields. This property can be used in materials science studies or radiobiology experiments to simulate the energy spectrum of space radiation exposures in a ground-based laboratory. However, the differences in effects between the higher dose rates of laser generated radiation and the lower dose rates of space radiation have to be investigated in separate, prior studies. A design for a high-throughput irradiation experiment and the associated Monte Carlo dose calculations for a broadband energy proton beam depositing energy in a cell monolayer is presented. Dose control and dose uniformity in the cell monolayer was achieved in the simulations using a variable thickness Ni attenuator. A set of target doses from 0.2 Gy to 4 Gy was obtained and dose uniformity was optimized to less than 4% variability. This work opens the possibility of single or multiple exposures, controllable, high-throughput irradiation experiments on biological samples or materials, using broadband energy particle beams generated by lasers, with relevance for space applications.
激光驱动辐射的一个特定特性是宽带能谱，这也是空间辐射场的一个特征。这一特性可用于材料科学研究或放射生物学实验，以在地面实验室中模拟空间辐射暴露的能谱。然而，激光产生的辐射的更高剂量率与空间辐射的更低剂量率之间的影响差异必须在单独的先前研究中进行调查。本文提出了一种高通量辐照实验的设计方案，并对在单层细胞中沉积能量的宽带能质子束进行了蒙特卡罗剂量计算。在模拟中，使用可变厚度的 Ni 衰减器来实现细胞单层中的剂量控制和剂量均匀性。获得了从 0.2Gy 到 4Gy 的一组靶剂量，并且将剂量均匀性优化到小于 4%的变化。这项工作为使用激光产生的宽带能粒子束对生物样本或材料进行单次或多次、可控制的高通量辐照实验提供了可能性，这对于空间应用具有重要意义。
