原发性胆汁性肝硬化患者外周血K细胞和活化T细胞数量减少。
Reduction in peripheral blood K cells and activated T cells in primary biliary cirrhosis.
作者信息
Sandilands G P, Macsween R N, Gray K G, Holden R J, Mills P, Reid F M, Thomas M A, Watkinson G
出版信息
Gut. 1977 Dec;18(12):1017-20. doi: 10.1136/gut.18.12.1017.
Abstract
Lymphocyte subpopulations were measured in the peripheral blood of 13 patients with primary biliary cirrhosis (PBC), 13 with chronic active hepatitis (CAH), and 16 age- and sex-matched normal subjects. A significant, relative and absolute, reduction in activated T cells and K cells, compared with that in normal subjects, was found in PBC but not in CAH. The reduction in K cells observed in PBC was found to be accompanied by a parallel decrease in lymphocyte-mediated antibody-dependent cytotoxicity.
摘要
对13例原发性胆汁性肝硬化（PBC）患者、13例慢性活动性肝炎（CAH）患者以及16例年龄和性别匹配的正常受试者的外周血淋巴细胞亚群进行了检测。与正常受试者相比，PBC患者的活化T细胞和K细胞出现了显著的相对和绝对减少，而CAH患者未出现这种情况。结果发现，PBC患者中观察到的K细胞减少伴随着淋巴细胞介导的抗体依赖性细胞毒性的平行下降。
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