El Nakeeb Noha, Saleh Shereen A, Massoud Yasmine M, Hussein Ahmed, Hamed Rana
Internal Medicine Department, Faculty of Medicine Ain Shams University Cairo Egypt.
Tropical Medicine Department, Faculty of Medicine Ain Shams University Cairo Egypt.
JGH Open. 2017 Nov 13;1(3):112-119. doi: 10.1002/jgh3.12019. eCollection 2017 Nov.
Many studies have found a relationship between hepatic iron, serum ferritin, and non-alcoholic fatty liver disease (NAFLD) or its progress. The aim of this study is to assess the value of serum ferritin as a non-invasive marker in the prediction of hepatic fibrosis in NAFLD.
This study included 113 subjects who were classified into three groups. Group I included 30 healthy subjects as control with no clinical, radiological, and histological features of NAFLD. Group II included 31 NAFLD patients without hepatic fibrosis. Group III included 52 patients with hepatic fibrosis on top of NAFLD.
Serum ferritin was determined using ferritin ELISA kit. Fibrosis 4 score was calculated. Liver biopsy was conducted for included patients. Significantly higher levels of serum ferritin were found in patients with hepatic fibrosis on top of NAFLD than controls. Receiver operating characteristic curve analysis revealed that an optimum cutoff level of 51.95 ng/mL was the best to predict fibrosis on top of NAFLD with diagnostic sensitivity and specificity of 65% and 60%, respectively, and area under the curve = 0.658.
Higher serum ferritin was found in patients with hepatic fibrosis on top of NAFLD. Serum ferritin was found to be a predictor of fibrosis on top of NAFLD with moderate sensitivity and specificity.
许多研究发现肝脏铁、血清铁蛋白与非酒精性脂肪性肝病（NAFLD）及其进展之间存在关联。本研究旨在评估血清铁蛋白作为一种非侵入性标志物在预测NAFLD肝纤维化中的价值。
本研究纳入113名受试者，分为三组。第一组包括30名健康受试者作为对照，无NAFLD的临床、影像学和组织学特征。第二组包括31名无肝纤维化的NAFLD患者。第三组包括52名除NAFLD外还患有肝纤维化的患者。
使用铁蛋白ELISA试剂盒测定血清铁蛋白。计算纤维化4评分。对纳入的患者进行肝活检。除NAFLD外还患有肝纤维化的患者血清铁蛋白水平显著高于对照组。受试者工作特征曲线分析显示，最佳截断水平为51.95 ng/mL时，预测除NAFLD外的纤维化效果最佳，诊断敏感性和特异性分别为65%和60%，曲线下面积 = 0.658。
除NAFLD外还患有肝纤维化的患者血清铁蛋白水平较高。血清铁蛋白被发现是除NAFLD外纤维化的一个预测指标，具有中等的敏感性和特异性。
