Bebington Brendan, Singh Elvira, Fabian June, Jan Kruger Christine, Prodehl Leanne, Surridge Daniel, Penny Clem, McNamara Lynne, Ruff Paul
Department of Surgery, Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa.
Wits Donald Gordon Medical Center Johannesburg South Africa.
JGH Open. 2018 Jun 6;2(4):139-143. doi: 10.1002/jgh3.12061. eCollection 2018 Aug.
Cancer is one of the foremost causes of morbidity and mortality worldwide. Globally, colorectal cancer (CRC) is the third most diagnosed and fourth most important cause of cancer death. A total of 70% of all CRC-related deaths occur in low- and middle-income countries. In Sub-Saharan Africa (SSA), estimating the burden of CRC is difficult. Only 27 of 43 SSA countries have formalized cancer registration systems; data quality is variable and national coverage rare.
This is a multidisciplinary, longitudinal cohort study started in January 2016. Patients >18 years with histologically confirmed primary adenocarcinoma of the colon and rectum, diagnosed within the previous 12 months, are eligible. Participants were assessed and were followed up for 3 years. Baseline information, including demographics, socioeconomic status, family history, medical and surgical non-cancer-related history, dietary history, colonoscopic findings, staging at presentation, treatment, and disease recurrence, is collected, as well as blood tests and histology results. Outcomes include disease recurrence (local and metastatic) and survival.
This study aims to describe the clinical presentation, management, and outcomes of adults with CRC in a multiethnic, urban South African population. It will be the first prospective study to describe clinical presentation, demographics, risk factors, treatment, and outcomes according to population group, from both private and state health-care facilities in Johannesburg, South Africa. The results of this study will be relevant not only to South Africa but also to other SSA countries undergoing similar rates of rapid urbanization and epidemiological transition.
癌症是全球发病和死亡的主要原因之一。在全球范围内，结直肠癌（CRC）是第三大最常被诊断出的癌症，也是第四大癌症死亡原因。所有与CRC相关的死亡中，有70%发生在低收入和中等收入国家。在撒哈拉以南非洲（SSA），估算CRC负担很困难。SSA的43个国家中只有27个建立了正式的癌症登记系统；数据质量参差不齐，全国覆盖率很低。
这是一项始于2016年1月的多学科纵向队列研究。年龄大于18岁、在过去12个月内被组织学确诊为结肠和直肠原发性腺癌的患者符合条件。对参与者进行评估并随访3年。收集基线信息，包括人口统计学、社会经济状况、家族史、与癌症无关的内科和外科病史、饮食史、结肠镜检查结果、就诊时的分期、治疗及疾病复发情况，以及血液检查和组织学结果。结局指标包括疾病复发（局部和转移）及生存情况。
本研究旨在描述南非城市多民族人群中成年CRC患者的临床表现、治疗及结局。这将是第一项前瞻性研究，描述南非约翰内斯堡私立和公立医疗机构中按人群分组的临床表现、人口统计学、危险因素、治疗及结局。本研究结果不仅对南非有意义，对其他正在经历类似快速城市化和流行病学转变的SSA国家也有意义。
