Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Adv Exp Med Biol. 2018;1103:305-307. doi: 10.1007/978-4-431-56847-6_17.
Among many kinds of somatic stem cells, hematopoietic stem cells are the cells that have been successfully applied to treating leukemia patients as forms of bone marrow and cord blood transplantation. Mesenchymal stem cells, collectable from several sources including the bone marrow and adipose tissue, are also widely applied to clinical trials for their easy accessibility and low risks of tumorigenesis, while their outcomes were shown to be not clinically relevant in several target diseases. The most important issue for the stem cells is whether the cells are safe and effective for curing diseases. In this chapter, the outline of the clinical trial in Muse cells is discussed.
在众多的成体干细胞中，造血干细胞是已经成功应用于治疗白血病患者的骨髓和脐带血移植的细胞。间充质干细胞可以从多种来源收集，包括骨髓和脂肪组织，也广泛应用于临床试验，因为它们易于获取且肿瘤形成风险低，尽管它们在一些目标疾病中的效果在临床上并不相关。对于干细胞来说，最重要的问题是细胞是否安全有效。在本章中，讨论了 Muse 细胞的临床试验概况。
