Interdisciplinary Graduate Program in Radiation Sciences, McMaster University, 1280 Main St. W., Hamilton, ON L8S 4L8, Canada.
Physiol Meas. 2018 Nov 28;39(11):115008. doi: 10.1088/1361-6579/aaedc6.
To report additional gadolinium bone and urine data that can contribute to gaps in knowledge with respect to gadolinium uptake and retention in the body.
In vivo measurements of gadolinium retention in the tibia bone were performed on individuals self-identified as exhibiting symptoms of gadolinium toxicity as a result of receiving GBCA, as well as on control individuals. Gadolinium urine measurements for controls, symptomatic exposed, and non-symptomatic exposed were conducted through Mayo Medical Laboratories.
Gadolinium bone concentration in the exposed group is significantly higher than the control group (p < 0.01), with a significant difference between symptomatic and non-symptomatic (p < 0.01), using a one-tailed t test on variance-weighted means. Gadolinium urine levels in both control subjects and non-symptomatic exposed subjects are significantly lower than symptomatic exposed subjects (p ≤ 0.05). A linear regression analysis for gadolinium urine levels and GBCA dose resulted in a positive linear relationship (R = 0.91, p < 0.01). Gadolinium levels in urine and gadolinium concentration in bone were found to have a non-significant relationship (R = 0.11, p = 0.3).
Significant differences in gadolinium levels in bone and urine are observed between individuals experiencing symptoms of gadolinium toxicity and for those who are not exhibiting symptoms. No correlation was observed between gadolinium in bone and gadolinium excreted in urine, suggesting that the retention of gadolinium in the body is complicated, involving multiple long-term storage sites.
报告额外的钆骨和尿数据，以填补有关体内钆摄取和保留知识空白。
对因接受 GBCA 而出现钆毒性症状的个体以及对照个体进行体内胫骨骨中钆保留的测量。通过 Mayo 医学实验室对对照个体、有症状暴露个体和无症状暴露个体进行钆尿测量。
暴露组的骨中钆浓度明显高于对照组（p < 0.01），症状组与无症状组之间存在显著差异（p < 0.01），采用方差加权均值的单侧 t 检验。对照个体和无症状暴露个体的钆尿水平均明显低于有症状暴露个体（p ≤ 0.05）。对钆尿水平和 GBCA 剂量进行线性回归分析，得到正线性关系（R = 0.91，p < 0.01）。尿中的钆水平和骨中的钆浓度之间存在非显著关系（R = 0.11，p = 0.3）。
在出现钆毒性症状的个体与未出现症状的个体之间，观察到骨中和尿中的钆水平存在显著差异。未观察到骨中钆与尿中排出的钆之间存在相关性，这表明体内钆的保留是复杂的，涉及多个长期储存部位。
