Department of Public Health, University of Naples Federico II, Naples, Italy.
Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
PLoS One. 2018 Nov 28;13(11):e0208064. doi: 10.1371/journal.pone.0208064. eCollection 2018.
To measure Optic Nerve Subarachnoid Space (ONSAS) in patients with primary open-angle glaucoma (POAG) and controls using A-scan ultrasound and to evaluate the measurement of the ONSAS in relation to age patient and OCT parameters.
This retrospective study included 53 consecutive eyes of 27 patients with POAG and 64 normal eyes of 32 controls. Both glaucomatous and control groups were divided into 2 subgroups according to age: <60 age (glaucomatous and control group 1) and 61-90 age (glaucomatous and control group 2).
The ONSAS was significantly lower in all glaucomatous eyes (3.54 ± 0.38) versus normal eyes (3.87 ± 0.32) (p = 0.001). Significant reduction of ONSAS was showed in control group 2 (3.63 mm ± 0.37) compared to control group 1 (3.87 mm ± 0.32) (p = 0.014) and between glaucoma group 1 (3.54 mm ± 0.38) and control group 1 (p = 0.001). While no significant differences were observed between glaucomatous group 2 (3.48 mm ± 0.41) and control group 2 (p = 0.17) and between glaucoma group 1 and glaucoma group 2 (p = 0.609). Lastly, the ONSAS was not significantly associated with GCC and RNFL parameters except for Focal Loss Volume (FLV), Superior RNFL and ONSAS in glaucoma group 1 and for FLV and ONSAS in all glaucomatous group.
Standardized A-scan ultrasound is a non invasive imaging technique with which it is possible to monitor ONSAS changes in glaucomatous patients. The reduction of ONSAS confirm the importance of the lower orbital CSFP as further risk factor in the progression of glaucoma disease.
使用 A 型超声测量原发性开角型青光眼（POAG）患者和对照者的视神经鞘蛛网膜下腔（ONSAS），并评估 ONSAS 测量与患者年龄和 OCT 参数的关系。
这是一项回顾性研究，纳入了 27 例 POAG 患者的 53 只连续眼和 32 例对照者的 64 只正常眼。将青光眼组和对照组均根据年龄分为 2 个亚组：<60 岁（青光眼组 1 和对照组 1）和 61-90 岁（青光眼组 2 和对照组 2）。
所有青光眼眼的 ONSAS 均显著低于正常眼（3.54 ± 0.38 比 3.87 ± 0.32）（p = 0.001）。与对照组 1（3.87 ± 0.32）相比，对照组 2（3.63 ± 0.37）的 ONSAS 显著降低（p = 0.014），且与青光眼组 1（3.54 ± 0.38）相比也显著降低（p = 0.001）。而青光眼组 2（3.48 ± 0.41）与对照组 2（p = 0.17）、青光眼组 1 与青光眼组 2（p = 0.609）之间的 ONSAS 无显著差异。最后，除了青光眼组 1 中的焦点丢失量（FLV）、上视网膜神经纤维层（RNFL）和 ONSAS，以及所有青光眼组中的 FLV 和 ONSAS 外，ONSAS 与 GCC 和 RNFL 参数均无显著相关性。
标准 A 型超声是一种非侵入性成像技术，通过该技术可以监测青光眼患者的 ONSAS 变化。ONSAS 的减少证实了眶下 CSFP 作为青光眼疾病进展的进一步危险因素的重要性。
