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巴西低收入社区原发性头痛预防的非药物治疗和生活方式改变:一项随机临床试验。

Non-Pharmacological Treatment for Primary Headaches Prevention and Lifestyle Changes in a Low-Income Community of Brazil: A Randomized Clinical Trial.

机构信息

Instituto do Cérebro, Hospital Israelita Albert Einstein, São Paulo, Brazil.

Faculdade de Medicina, Instituto de Psiquiatria, Universidade de São Paulo, São Paulo, Brazil.

出版信息

Headache. 2019 Jan;59(1):86-96. doi: 10.1111/head.13457. Epub 2018 Nov 28.

DOI:10.1111/head.13457
PMID:30485409
Abstract

BACKGROUND

Primary headaches can be reduced by lifestyle changes, such as stress management and physical activity. However, access to programs focused on behavioral interventions is limited in underserved, poor communities.

OBJECTIVES

We performed a randomized open-label clinical trial to test the therapeutic and behavioral effects of aerobic exercise, relaxation, or the combination of both, in individuals with primary headaches of a small, low-income community of the Brazilian Amazon.

METHODS

Participants were screened from the riverine/rural population, and individuals with primary headache were included. We assessed clinical characteristics and physical activity levels. Interventions were delivery 3 times/week for 6 months. The primary outcome variable was changes in days with headache, while changes in duration of attacks, pain intensity, and physical activity levels were secondary outcomes variables.

RESULTS

Seven hundred and ninety individuals were screened (15.3% of rural/riverine population). Seventy-four participants were randomly assigned to relaxation (n = 25), physical activity orientation program (n = 25), or both (n = 24) interventions. Intention to treat analyses showed all interventions as effective to reduce days with headaches and duration of attacks (both P < .01). Pain intensity was reduced only in relaxation and relaxation + physical activity groups (both P < .01). Physical activity levels increased only in the relaxation + physical activity group (P < .05).

CONCLUSIONS

Non-pharmacological interventions such as physical activity and relaxation are effective for reducing headaches, while combining such interventions promote health behavior toward higher physical activity levels in low-income populations with primary headaches.

CLINICAL TRIAL REGISTRATION NUMBER

SGPP 1544.

摘要

背景

生活方式的改变,如压力管理和身体活动,可以减少原发性头痛。然而,在服务不足和贫困社区,获得专注于行为干预的项目的机会有限。

目的

我们进行了一项随机开放标签临床试验,以测试有氧运动、放松或两者结合对巴西亚马逊地区一个小型低收入社区原发性头痛患者的治疗和行为影响。

方法

从河滨/农村人口中筛选参与者,并纳入原发性头痛患者。我们评估了临床特征和身体活动水平。干预措施是每周进行 3 次,持续 6 个月。主要结局变量是头痛天数的变化,而发作持续时间、疼痛强度和身体活动水平的变化是次要结局变量。

结果

共筛查了 790 人(占农村/河滨人口的 15.3%)。74 名参与者被随机分配到放松组(n=25)、身体活动定向计划组(n=25)或两者结合组(n=24)。意向治疗分析表明,所有干预措施均有效减少头痛天数和发作持续时间(均 P<0.01)。只有在放松和放松+身体活动组中疼痛强度降低(均 P<0.01)。只有在放松+身体活动组中身体活动水平增加(P<0.05)。

结论

非药物干预,如身体活动和放松,对减少头痛有效,而结合这些干预措施可以促进低收入原发性头痛人群的健康行为,提高身体活动水平。

临床试验注册号

SGPP 1544。

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