血管内皮生长因子：从基础研究到临床应用。
Vascular Endothelial Growth Factor, from Basic Research to Clinical Applications.
机构信息
Biomolecular Research, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Biocenter of the University of Basel, 4056 Basel, Switzerland.
出版信息
Int J Mol Sci. 2018 Nov 26;19(12):3750. doi: 10.3390/ijms19123750.
Abstract
Judah Folkman's landmark discovery in the 1970s showing that tumors, growing beyond a few millimeters in diameter, depend on de novo vascularization triggered by specific growth factors released by tumor cells encountering hypoxia [...].
摘要
20 世纪 70 年代，犹大·福克曼（Judah Folkman）的开创性发现表明，肿瘤在直径超过几毫米后，依赖于肿瘤细胞遇到缺氧时释放的特定生长因子触发的新血管生成[... ]。
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