Zhang Qingfu, Su Jianyao, Li Zhichao, Han Su, Wang Chuanhe, Sun Zhijun
Department of Cardiology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, 11000, Liaoning Province, People's Republic of China.
J Nanobiotechnology. 2025 Apr 20;23(1):302. doi: 10.1186/s12951-025-03362-6.
Migrasomes are newly identified organelles that were first discovered in 2015. Since then, their biological structure, formation process, and physiological functions have been gradually elucidated. Research in recent years has expanded our understanding of these aspects, highlighting their significance in various physiological and pathological processes. Migrasomes have been found to play crucial roles in normal physiological functions, including embryonic development, vascular homeostasis, material transport, and mitochondrial quality control. Additionally, emerging evidence suggests their involvement in various diseases; however, clinical research on their roles remains limited. Current studies indicate that migrasomes may contribute to disease pathogenesis and hold potential for diagnostic and therapeutic applications. This review consolidates existing clinical research on migrasomes, focusing on their role in disease mechanisms and their use in medical applications. By examining their biological structure and function, this review aims to generate insights that encourage further research, ultimately contributing to advancements in disease prevention and treatment.
迁移小体是2015年首次发现的新鉴定细胞器。从那时起，它们的生物学结构、形成过程和生理功能逐渐得以阐明。近年来的研究扩展了我们对这些方面的理解，突显了它们在各种生理和病理过程中的重要性。已发现迁移小体在正常生理功能中发挥关键作用，包括胚胎发育、血管稳态、物质运输和线粒体质量控制。此外，新出现的证据表明它们与各种疾病有关；然而，关于它们作用的临床研究仍然有限。目前的研究表明，迁移小体可能参与疾病发病机制，并具有诊断和治疗应用潜力。本综述整合了关于迁移小体的现有临床研究，重点关注它们在疾病机制中的作用及其在医学应用中的用途。通过研究它们的生物学结构和功能，本综述旨在产生鼓励进一步研究的见解，最终推动疾病预防和治疗的进展。
