长链非编码 RNA CYTOR 通过海绵吸附 miR-195 来调节非小细胞肺癌细胞的增殖、迁移、侵袭和放射敏感性。

Long noncoding RNA CYTOR sponges miR-195 to modulate proliferation, migration, invasion and radiosensitivity in nonsmall cell lung cancer cells.

机构信息

Cancer Department, The People's Hospital of China Three Gorges University, Yichang city, Hubei Province 443000, China.

Emergency Department, The First College of Clinical Medical Science, China Three Gorges University, Yichang city, Hubei Province 443002, China

出版信息

Biosci Rep. 2018 Dec 18;38(6). doi: 10.1042/BSR20181599. Print 2018 Dec 21.

Nonsmall cell lung cancer (NSCLC) is one of the most frequent malignancies worldwide. Long noncoding RNAs (LncRNAs) play critical roles in cancer initiation and progression. Previous studies have demonstrated that overexpression of cytoskeleton regulator RNA (CYTOR) predicates poor prognosis and promotes tumor progression. However, the functional roles and underlying mechanism of CYTOR in NSCLC remain unknown. In the present study, we found that CYTOR promoted cell proliferation, migration and invasion ability, and induced radioresistance in NSCLC cells. Mechanistically, CYTOR could directly interact with miR-195 and increase its targets. Thus, CYTOR played an oncogenic role in NSCLC progression through sponging miR-195. Together, our study elucidates the role of CYTOR as a microRNA sponge in NSCLC, and CYTOR may be used as a promising therapeutic target for NSCLC treatment.

非小细胞肺癌（NSCLC）是全球最常见的恶性肿瘤之一。长链非编码 RNA（lncRNA）在癌症的发生和发展中起着关键作用。先前的研究表明，细胞骨架调节 RNA（CYTOR）的过表达预示着预后不良，并促进肿瘤的进展。然而，CYTOR 在非小细胞肺癌中的功能作用和潜在机制尚不清楚。在本研究中，我们发现 CYTOR 促进了非小细胞肺癌细胞的增殖、迁移和侵袭能力，并诱导了其放射抵抗性。机制上，CYTOR 可以直接与 miR-195 相互作用并增加其靶标。因此，CYTOR 通过海绵吸附 miR-195 在非小细胞肺癌的进展中发挥致癌作用。总之，我们的研究阐明了 CYTOR 作为非小细胞肺癌中 microRNA 海绵的作用，CYTOR 可能作为非小细胞肺癌治疗的有前途的治疗靶点。