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连接性和网络状态依赖性招募小鼠海马中的长程 VIP-GABA 能神经元。

Connectivity and network state-dependent recruitment of long-range VIP-GABAergic neurons in the mouse hippocampus.

机构信息

Neuroscience Axis, CHU de Québec Research Center, Université Laval, Quebec, QC, G1V 4G2, Canada.

Department of Biochemistry, Microbiology and Bio-informatics, Université Laval, Quebec, QC, G1V 0A6, Canada.

出版信息

Nat Commun. 2018 Nov 28;9(1):5043. doi: 10.1038/s41467-018-07162-5.

DOI:10.1038/s41467-018-07162-5
PMID:30487571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6261953/
Abstract

GABAergic interneurons in the hippocampus provide for local and long-distance coordination of neurons in functionally connected areas. Vasoactive intestinal peptide-expressing (VIP+) interneurons occupy a distinct niche in circuitry as many of them specialize in innervating GABAergic cells, thus providing network disinhibition. In the CA1 hippocampus, VIP+ interneuron-selective cells target local interneurons. Here, we discover a type of VIP+ neuron whose axon innervates CA1 and also projects to the subiculum (VIP-LRPs). VIP-LRPs show specific molecular properties and target interneurons within the CA1 area but both interneurons and pyramidal cells within subiculum. They are interconnected through gap junctions but demonstrate sparse spike coupling in vitro. In awake mice, VIP-LRPs decrease their activity during theta-run epochs and are more active during quiet wakefulness but not coupled to sharp-wave ripples. Together, the data provide evidence for VIP interneuron molecular diversity and functional specialization in controlling cell ensembles along the hippocampo-subicular axis.

摘要

海马体内的 GABA 能中间神经元为功能连接区域的神经元提供局部和远距离的协调。表达血管活性肠肽 (VIP+) 的中间神经元在回路中占据独特的位置，因为它们中的许多神经元专门支配 GABA 能细胞，从而提供网络抑制。在 CA1 海马体中，VIP+中间神经元选择性细胞靶向局部中间神经元。在这里，我们发现了一种 VIP+神经元，其轴突支配 CA1 并投射到下托（VIP-LRPs）。VIP-LRPs 表现出特定的分子特性，并在 CA1 区域内靶向中间神经元，但也靶向下托内的中间神经元和锥体细胞。它们通过缝隙连接相互连接，但在体外显示稀疏的尖峰耦合。在清醒的小鼠中，VIP-LRPs 在 theta 运行期间降低其活动，并在安静的清醒期间更活跃，但不与尖峰涟漪耦合。总之，这些数据为 VIP 中间神经元的分子多样性和在沿着海马-下托轴控制细胞群的功能专业化提供了证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8ae/6261953/bf805e0ff00c/41467_2018_7162_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8ae/6261953/a17b76a44937/41467_2018_7162_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8ae/6261953/46f5d9bb997d/41467_2018_7162_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8ae/6261953/0864bf6dd85e/41467_2018_7162_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8ae/6261953/9f8fbb69dda9/41467_2018_7162_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8ae/6261953/bf805e0ff00c/41467_2018_7162_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8ae/6261953/a17b76a44937/41467_2018_7162_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8ae/6261953/c6d4a253e8ea/41467_2018_7162_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8ae/6261953/c0aaeeeaa399/41467_2018_7162_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8ae/6261953/46f5d9bb997d/41467_2018_7162_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8ae/6261953/0864bf6dd85e/41467_2018_7162_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8ae/6261953/9f8fbb69dda9/41467_2018_7162_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8ae/6261953/bf805e0ff00c/41467_2018_7162_Fig7_HTML.jpg

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