Doja Asif, Bookwala Ammar, Pohl Daniela, Rossi-Ricci Alessandra, Barrowman Nicholas, Chan Jason, Longmuir Patricia E
Faculty of Medicine, University of Ottawa, Ottawa, Ontario.
Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario.
J Can Acad Child Adolesc Psychiatry. 2018 Nov;27(4):222-227. Epub 2018 Nov 1.
To examine the relationship between physical activity, tic severity and quality of life (QoL) in children and adolescents with persistent tic disorder and Tourette Syndrome.
Baseline data was examined from a larger randomized controlled trial (Clinicaltrials.gov NCT02153463). Physical activity was assessed via pedometers with daily step count recorded. Tic severity (assessed via Yale Global Tic Severity Scale or YGTSS) and QoL (assessed via PEDs QL 4.0) were compared between those more physically active (≥12,000 steps/day) and less physically active (<12,000 steps/day).
Thirteen children participated; four had ≥12,000 steps/day and nine had <12,000 steps/day. The active group had a lower total tic severity (p = 0.02), and total YGTSS score (p=0.01). The vocal tic severity score was lower in the active group (p=0.02). Motor tic severity was not different amongst the two groups. For Peds QL scores, the active group performed better in physical functioning (p=0.01), social functioning (p=0.03), school functioning (p=0.02), psychosocial functioning (p=0.03) and total PEDs QL score (p=0.01).
Higher physical activity levels are associated with lower vocal tic severity and improved aspects of quality of life. Further research is needed to determine the utility of physical activity as therapy for tics.
探讨患有持续性抽动障碍和妥瑞氏综合征的儿童及青少年的身体活动、抽动严重程度与生活质量（QoL）之间的关系。
对一项更大规模的随机对照试验（Clinicaltrials.gov NCT02153463）的基线数据进行分析。通过计步器评估身体活动情况，记录每日步数。比较身体活动较多（≥12,000步/天）和身体活动较少（<12,000步/天）的两组患者的抽动严重程度（通过耶鲁综合抽动严重程度量表或YGTSS评估）和生活质量（通过PEDs QL 4.0评估）。
13名儿童参与研究；4名儿童每日步数≥12,000步，9名儿童每日步数<12,000步。活动量较大的组总抽动严重程度较低（p = 0.02），YGTSS总分较低（p = 0.01）。活动量较大的组发声抽动严重程度得分较低（p = 0.02）。两组之间运动抽动严重程度无差异。对于PEDs QL得分，活动量较大的组在身体功能（p = 0.01）、社会功能（p = 0.03）、学校功能（p = 0.02）、心理社会功能（p = 0.03）和PEDs QL总分（p = 0.01）方面表现更好。
较高的身体活动水平与较低的发声抽动严重程度及生活质量的改善相关。需要进一步研究以确定身体活动作为抽动症治疗方法的效用。
