Degiannis D, Mowat A M, Tsakiris D, Briggs J D, Junor B J, Parrott D M
Department of Bacteriology and Immunology, Western Infirmary, Glasgow, Scotland.
Clin Exp Immunol. 1988 Jul;73(1):155-9.
The effect of blood transfusion on humoral immunity in chronic renal failure was studied by examining immunoglobulin production in vitro, in patients awaiting renal transplantation. Pokeweed mitogen (PWM) induced IgG plaque formation was normal in non-transfused uraemic patients while both spontaneous and Staphylococcus aureus Cowan I (SAC) induced immunoglobulin production were reduced. Five to ten units of third party blood transfusion reduced PWM-driven B cell differentiation, but had no effect on SAC-induced plaque formation, while spontaneous production of immunoglobulin was either enhanced or unaffected. As it is known that the response to SAC is less affected by suppressor T cell activity than that to PWM, these differences in the inhibitory effects of blood transfusion on B cell differentiation are further evidence that transfusion may act by increasing suppressor T cell activity.
通过检测等待肾移植患者的体外免疫球蛋白生成情况，研究了输血对慢性肾衰竭患者体液免疫的影响。在未输血的尿毒症患者中，商陆有丝分裂原（PWM）诱导的IgG噬斑形成正常，而自发和金黄色葡萄球菌Cowan I（SAC）诱导的免疫球蛋白生成均减少。输注5至10单位第三方血液可降低PWM驱动的B细胞分化，但对SAC诱导的噬斑形成无影响，而免疫球蛋白的自发生成则增强或未受影响。由于已知对SAC的反应受抑制性T细胞活性的影响小于对PWM的反应，输血对B细胞分化抑制作用的这些差异进一步证明输血可能通过增加抑制性T细胞活性起作用。
