Bioelectrical Engineering Lab, Electrical Engineering, Inha University, 100 Inha-ro, Michuhol-gu, Incheon, 22212, South Korea.
Electrical Engineering, Inha University, 100 Inha-ro, Michuhol-gu, Incheon, 22212, South Korea.
Lasers Med Sci. 2019 Jul;34(5):1031-1039. doi: 10.1007/s10103-018-2693-4. Epub 2018 Nov 28.
Characteristics such as skin tone and pigmentation color vary among patients, but most researches on laser irradiation in laser ablation have revolved around minimizing damage to reduce pain. Chromophores are the most important factors in photon energy absorption, a key principle of laser ablation. We investigated the influences on ablation depth by different chromophores on the target and modulating duration per laser exposure using an Nd:YVO4 nanosecond 532-nm laser. We used a Fourier-domain optical coherence tomography (Fd-OCT) system combined with a 532-nm Nd:YVO4 laser to observe the ablation process. In addition, an external customized shutter and water-based color pens (red, green, blue, black) were used to determine the effects of modulating the duration per laser exposure and coloring chromophores on porcine skin and hairless mouse models. Experiments with modulating duration per laser exposure demonstrated that shorter duration generated shallower craters than longer one. Painted experimental group showed damaged region as craters in the experiments with coloring various chromophores. In this research, we investigated the effects of modulating duration per laser exposure and different chromophores on the target. Coloring chromophores with water-based dyes using pens increased tissue damage without dyeing cells or tissue.
患者的肤色和色素沉着颜色等特征各不相同，但激光烧蚀中激光照射的大多数研究都集中在尽量减少损伤以减轻疼痛上。光吸收的最重要因素是色团，这是激光烧蚀的关键原理。我们使用纳秒 532nmNd:YVO4 激光研究了不同靶材色团对烧蚀深度的影响以及每激光曝光调制持续时间的影响。我们使用傅里叶域光学相干断层扫描（Fd-OCT）系统结合 532nmNd:YVO4 激光来观察烧蚀过程。此外，还使用外部定制快门和水性彩笔（红、绿、蓝、黑）来确定调制每激光曝光持续时间和对猪皮和无毛小鼠模型的着色色团的影响。调制每激光曝光持续时间的实验表明，持续时间越短，形成的坑就越浅。在各种色团着色的实验中，画实验组显示出的损伤区域为坑。在这项研究中，我们研究了调制每激光曝光持续时间和目标中不同色团的影响。使用笔对水性染料进行着色会增加组织损伤，而不会对细胞或组织进行染色。
