Wessels R, De Bruin D M, Faber D J, Van Leeuwen T G, Van Beurden M, Ruers T J M
Department of Surgical Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, PO Box 90203, Amsterdam, 1006 BE, The Netherlands,
Lasers Med Sci. 2014 May;29(3):1297-305. doi: 10.1007/s10103-013-1291-8. Epub 2013 Mar 16.
Optical coherence tomography (OCT) is an optical technique that measures the backscattering of near-infrared light by tissue. OCT yields in 2D and 3D images at micrometer-scale resolution, thus providing optical biopsies, approaching the resolution of histopathological imaging. The technique has shown to allow in vivo differentiation between benign and malignant epithelial tissue, through qualitative assessment of OCT images, as well as by quantitative evaluation, e.g., functional OCT. This study aims to summarize the principles of OCT and to discuss the current literature on the diagnostic value of OCT in the diagnosis of epithelial (pre)malignant lesions. The authors did a systematic search of the electronic databases PubMed and Embase on OCT in the diagnostic process of (pre)malignant epithelial lesions. OCT is able to differentiate between benign and (pre)malignant lesions of epithelial origin in a wide variety of tissues. In this way, OCT can detect skin cancers, oral, laryngeal, and esophageal cancer as well as genital and bladder cancer. OCT is an innovative technique which enables an optical biopsy of epithelial lesions. The incorporation of OCT in specific tools, like handheld and catheter-based probes, will further improve the implementation of this technology in daily clinical practice.
光学相干断层扫描（OCT）是一种光学技术，用于测量组织对近红外光的反向散射。OCT能够以微米级分辨率生成二维和三维图像，从而提供光学活检，其分辨率接近组织病理学成像。通过对OCT图像的定性评估以及定量评估（如功能性OCT），该技术已显示出能够在体内区分良性和恶性上皮组织。本研究旨在总结OCT的原理，并讨论目前关于OCT在诊断上皮性（癌前）病变中的诊断价值的文献。作者对电子数据库PubMed和Embase进行了系统检索，以查找有关OCT在（癌前）恶性上皮病变诊断过程中的研究。OCT能够在多种组织中区分上皮来源的良性和（癌前）恶性病变。通过这种方式，OCT可以检测皮肤癌、口腔癌、喉癌和食管癌以及生殖器癌和膀胱癌。OCT是一种创新技术，能够对上皮病变进行光学活检。将OCT集成到特定工具中，如手持式和基于导管的探头，将进一步改善该技术在日常临床实践中的应用。
