Department of Chemistry, Kansas State University, Manhattan, Kansas 66506, USA.
Chem Commun (Camb). 2018 Dec 13;54(100):14047-14060. doi: 10.1039/c8cc08135b.
From discrete and dispersed to condensed and organized, directed assembly provides a link between molecular structure and macroscopic properties. If we are able to combine several different molecular entities within the same crystalline lattice and make co-crystals, then we can also access a wider chemical space whilst circumventing the need for complex covalent synthesis. Co-crystal technology can offer versatile avenues for the design and preparation of new solid forms that have tunable physical properties. All of this, however, requires an improved understanding of intermolecular interactions-over the full range of molecular size and structure. In this perspective, we highlight some strategies and protocols that have been developed in order to synthesize co-crystals with predetermined and desirable structural features.
从离散和分散到凝聚和有组织，定向组装在分子结构和宏观性质之间提供了联系。如果我们能够在同一晶格中组合几种不同的分子实体并形成共晶，那么我们还可以访问更广泛的化学空间，同时避免复杂的共价合成的需要。共晶技术可以为设计和制备具有可调物理性质的新型固态形式提供多种途径。然而，所有这一切都需要更好地了解分子尺寸和结构范围内的分子间相互作用。在这篇观点文章中，我们强调了一些已经开发出的策略和方案，以便用预定的和期望的结构特征来合成共晶。
