白头小奥德蘑中一种具有抗菌活性的倍半萜类化合物——白头小奥德蘑酮 A
Antroalbocin A, an Antibacterial Sesquiterpenoid from Higher Fungus Antrodiella albocinnamomea.
机构信息
School of Pharmaceutical Sciences , South-Central University for Nationalities , Wuhan 430074 , China.
出版信息
Org Lett. 2018 Dec 21;20(24):8019-8021. doi: 10.1021/acs.orglett.8b03595. Epub 2018 Nov 29.
PMID:30489092
Abstract
Antroalbocin A (1), a sesquiterpenoid possessing a bridged tricyclic system, was isolated from cultures of the higher fungus Antrodiella albocinnamomea (Basidiomycota). The structure with the absolute configuration was determined by extensive spectroscopic methods and single-crystal X-ray diffraction. A plausible biosynthetic pathway for 1 was proposed. Compound 1 was found to inhibit Staphylococcus aureus with an MIC value of 169 μM.
摘要
化合物 1 被发现对金黄色葡萄球菌具有抑制活性，MIC 值为 169 μM。
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