School of Pharmaceutical Sciences, South-Central Minzu University, 182 Minzu Road, Wuhan 430074, P.R. China.
National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand.
Org Biomol Chem. 2022 Sep 21;20(36):7278-7283. doi: 10.1039/d2ob01443b.
Antroxazole A (1), a chamigrane type sesquiterpene dimer containing an oxazole moiety, has been characterized from cultures of the fungus . The structure with absolute configuration was determined by extensive spectroscopic methods and single crystal X-ray diffraction. A plausible biosynthetic pathway for 1 was proposed. Compound 1 exhibits inhibition specifically against the LPS-induced proliferation of B lymphocyte cells with an IC value of 16.3 μM.
烯唑醇 A（1），一种含有恶唑基部分的查耳酮型倍半萜二聚体，已从真菌的培养物中得到鉴定。通过广泛的光谱方法和单晶 X 射线衍射确定了其结构和绝对构型。提出了 1 的可能生物合成途径。化合物 1 对 LPS 诱导的 B 淋巴细胞增殖具有特异性抑制作用，IC 值为 16.3 μM。
