Serviço de Imunoalergologia, Centro Hospitalar de São João, Porto, Portugal.
R&D Department, Zamudio, Bilbao, Spain.
Occup Med (Lond). 2018 Dec 26;68(9):641-643. doi: 10.1093/occmed/kqy159.
Cassia angustifolia, or senna, is a plant belonging to the Fabaceae family, widely used as a laxative and as a colouring agent in hair dyes. Senna is rarely reported as an occupational allergic sensitizer in the current literature.
To describe the case and diagnostic approach of a suspected occupational senna allergy.
A male phytopharmaceutical warehouse worker reported bronchial, conjunctival and nasal symptoms immediately upon exposure to senna. We were able to document in vitro sensitization, finding IgE-binding proteins in senna, and in vivo sensitization through positive skin tests and conjunctival provocation test.
Our study confirms that senna may cause occupational rhinoconjunctivitis symptoms with an IgE-dependent mechanism and is the first to confirm it through specific conjunctival provocation test.
狭叶番泻，又称番泻叶，是豆科植物，被广泛用作泻药和染发剂的着色剂。番泻叶在当前文献中很少被报道为职业性变应原致敏物。
描述疑似职业性番泻叶过敏的病例和诊断方法。
一名男性植物制药仓库工人在接触番泻叶后立即出现支气管、结膜和鼻症状。我们能够通过体外致敏实验在番泻叶中发现 IgE 结合蛋白，并通过阳性皮肤试验和结膜激发试验证实体内致敏。
我们的研究证实番泻叶可能引起 IgE 依赖性机制的职业性鼻结膜炎症状，并且是首次通过特异性结膜激发试验证实。
