Endocrinology Research Laboratory, Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysuru 570006, Karnataka, India.
Endocrinology Research Laboratory, Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysuru 570006, Karnataka, India.
Eur J Pharmacol. 2019 Jan 15;843:233-239. doi: 10.1016/j.ejphar.2018.11.034. Epub 2018 Nov 26.
Diabetes mellitus is the most common endocrine disorder characterized by hyperglycemia resulting from defects in insulin secretion or insulin action. The present study was designed to investigate the antidiabetic effects of vincamine, one of the monoterpenoid indole alkaloid, in streptozotocin-induced diabetic rat model. Diabetes was induced in rats by an intraperitoneal injection of streptozotocin (40 mg/kg bw). Vincamine 20 and 30 mg/kg.bw were administrated orally as a single dose per day to the diabetic rats for 30 days. The vehicle control group received 0.5% dimethyl sulfoxide for the same duration. After 30 days of treatment, fasting blood glucose, glycosylated haemoglobin, total cholesterol, triglyceride, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol levels were significantly increased, whereas, body weight, plasma insulin, high-density lipoprotein cholesterol, antioxidant enzymes and reduced glutathione were markedly decreased in diabetic rats. Treatment with vincamine significantly restored these parameters to the normal level. The protective effect of vincamine was compared with glibenclamide, a well-known hypoglycemic drug. Our results clearly suggest that vincamine exhibit hypoglycemic, hypolipidemic and antioxidant activity. The anti-diabetic effect of vincamine was comparable to the protective effect of glibenclamide, suggesting its potential as a natural anti-diabetic compound with therapeutic benefits.
糖尿病是最常见的内分泌紊乱疾病，其特征是由于胰岛素分泌或作用缺陷导致的高血糖。本研究旨在探讨长春胺（一种单萜吲哚生物碱）在链脲佐菌素诱导的糖尿病大鼠模型中的降血糖作用。通过腹腔注射链脲佐菌素（40mg/kg 体重）诱导大鼠糖尿病。长春胺 20 和 30mg/kg.bw 作为单剂量每天口服给予糖尿病大鼠 30 天。对照组给予相同持续时间的 0.5%二甲基亚砜。治疗 30 天后，糖尿病大鼠的空腹血糖、糖化血红蛋白、总胆固醇、甘油三酯、低密度脂蛋白胆固醇和极低密度脂蛋白胆固醇水平显著升高，而体重、血浆胰岛素、高密度脂蛋白胆固醇、抗氧化酶和还原型谷胱甘肽显著降低。长春胺治疗可显著将这些参数恢复到正常水平。将长春胺的保护作用与已知的降血糖药物格列本脲进行比较。我们的结果清楚地表明，长春胺具有降血糖、降血脂和抗氧化作用。长春胺的抗糖尿病作用与格列本脲的保护作用相当，表明其具有作为天然抗糖尿病化合物的潜力，具有治疗益处。
