Department of Clinical Bio-bank, Nantong University Affiliated Hospital, Nantong, Jiangsu 226001, China; Department of Pathology, Medical School of Nantong University, Nantong, Jiangsu 226001, China.
Department of General Surgery, Nantong University Affiliated Hospital, Nantong, Jiangsu 226001, China.
Hum Pathol. 2019 Apr;86:49-56. doi: 10.1016/j.humpath.2018.11.019. Epub 2018 Nov 26.
Alkaline phosphatase placental-like 2 (ALPPL2) is a member of the ALPP alkaline phosphatase family and is reported to be associated with the growth of some tumors. Gastric cancer is one of the most common cancers worldwide. We previously identified a distinct expression pattern of ALPPL2 between gastric cancer and adjacent normal tissues. In this study, we examined the expression of ALPPL2 in gastric adenocarcinoma and its ability to predict prognosis. We used bioinformatics analysis and immunohistochemistry to examine the expression pattern of ALPPL2 and analyzed the associations between ALPPL2 level and perioperative characteristics and the prognosis of gastric adenocarcinoma patients by Kaplan-Meier plotter analysis. Our results indicated that the expression of ALPPL2 was significantly increased in gastric adenocarcinoma (P < .01) and was an independent factor (P < .05) that could provide reliable prognostic information on gastric adenocarcinoma patients. High expression of ALPPL2 was associated with advanced TNM stage (P < .05) and high HER-2 expression (P < .01). Our study suggests that ALPPL2 has the potential to reveal prognostic information on gastric cancer.
碱性磷酸酶胎盘样 2（ALPPL2）是 ALPP 碱性磷酸酶家族的一员，据报道与一些肿瘤的生长有关。胃癌是全球最常见的癌症之一。我们之前在胃癌和相邻正常组织之间发现了 ALPPL2 的明显表达模式。在这项研究中，我们研究了 ALPPL2 在胃腺癌中的表达及其预测预后的能力。我们使用生物信息学分析和免疫组织化学检测了 ALPPL2 的表达模式，并通过 Kaplan-Meier plotter 分析分析了 ALPPL2 水平与围手术期特征和胃腺癌患者预后之间的关联。我们的结果表明，ALPPL2 在胃腺癌中的表达显著增加（P<.01），并且是一个独立的因素（P<.05），可以为胃腺癌患者提供可靠的预后信息。ALPPL2 的高表达与较晚的 TNM 分期（P<.05）和高 HER-2 表达（P<.01）相关。我们的研究表明，ALPPL2 有可能揭示胃癌的预后信息。
