高表达 HBO1 预测胃癌预后不良。
High-Expression HBO1 Predicts Poor Prognosis in Gastric Cancer.
机构信息
Department of Pathology, Affiliated Hospital of Nantong University, Nantong, China.
Department of Medical Imaging and Laboratory, Xiangnan University, Chenzhou, China.
出版信息
Am J Clin Pathol. 2019 Sep 9;152(4):517-526. doi: 10.1093/ajcp/aqz065.
OBJECTIVES
Our goal was to assess the expression of histone acetyltransferase binding to origin recognition complex 1 (HBO1) in gastric cancer and the effect on prognosis for the patients.
METHODS
We used quantitative reverse transcription polymerase chain reaction, Western blot, and tissue microarray immunohistochemistry to investigate the expressions of HBO1 messenger RNA (mRNA) and protein in gastric cancer tissues. Online resources, including Oncomine and Kaplan-Meier Plotter, were used to further assess the correlation between HBO1 expression and the prognosis of the patients with gastric cancer.
RESULTS
HBO1 mRNA and protein expressions in gastric cancer tissues were both significantly higher than those in normal tissues. The correlations between high HBO1 expression and differentiation, invasive depth (T), lymph node metastasis (N), distant metastasis (M), TNM staging, and serum carcinoembryonic antigen levels were positive. High HBO1 expression was negatively correlated with survival time in patients with gastric cancer.
CONCLUSIONS
HBO1 might be a valuable biomarker to evaluate the prognosis of patients with gastric cancer.
目的
评估组蛋白乙酰转移酶结合到起始识别复合物 1（HBO1）在胃癌中的表达及其对患者预后的影响。
方法
我们使用定量逆转录聚合酶链反应、Western blot 和组织微阵列免疫组织化学来研究 HBO1 信使 RNA（mRNA）和蛋白在胃癌组织中的表达。在线资源，包括 Oncomine 和 Kaplan-Meier Plotter，用于进一步评估 HBO1 表达与胃癌患者预后之间的相关性。
结果
胃癌组织中 HBO1 mRNA 和蛋白的表达均明显高于正常组织。高 HBO1 表达与分化、浸润深度（T）、淋巴结转移（N）、远处转移（M）、TNM 分期和血清癌胚抗原水平呈正相关。高 HBO1 表达与胃癌患者的生存时间呈负相关。
结论
HBO1 可能是评估胃癌患者预后的有价值的生物标志物。
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