Haude M, Brennecke R, Erbel R, Jung D, Kiefer E, Schmidt T, Meyer J
II. Medical Clinic, Johannes Gutenberg University, Mainz, FRG.
Int J Card Imaging. 1988;3(2-3):127-32. doi: 10.1007/BF01814885.
From densitometric evaluation of digital subtraction cineangiocardiograms the parameter 'Mean Rise Time' (MRT), defined as the time from the onset of local myocardial contrast medium opacification to the point of maximal opacification can be derived; this parameter revealed a close correlation with the results on myocardial perfusion obtained by Thallium-201 scintigraphy. A prolonged 'Mean Rise Time' was indicative of an impairment of myocardial perfusion. We have developed a heart-phase gated real-time digitization procedure and computer-supported method for the densitometric estimation of the MRT to obtain information about the effect of coronary balloon dilatation on myocardial perfusion before and after stimulation of coronary flow reserve by Moxaverin. In 22 patients with single vessel coronary artery disease Moxaverin caused a significant prolongation of the post-stenotic MRT (2.3 +/- 1.2s (mean +/- s.d.) vs. 2.9 +/- 1.1s, p less than 0.05), while after successful dilatation of the obstructive lesion a significant shortening of the MRT was found after stimulation of the coronary flow reserve (2.5 +/- 1.2s vs. 1.9 +/- 0.9s, p less than 0.05). A highly significant decrease in MRT after Moxaverin was measured post-dilatation in comparison to the initial pre-dilatation results (2.9 +/- 1.1s vs. 1.9 +/- 0.9s, p less than 0.005); this shows that the effect of successful balloon dilatation on the post-stenotic myocardial perfusion can be described very well by this parameter. These results demonstrate that information about post-stenotic myocardial perfusion during interventional heart catheterization can be obtained from digital densitometry.
通过对数字减法电影心血管造影进行密度测定评估，可以得出参数“平均上升时间”（MRT），其定义为局部心肌对比剂开始显影至最大显影点的时间；该参数与铊-201闪烁显像获得的心肌灌注结果密切相关。“平均上升时间”延长表明心肌灌注受损。我们开发了一种心脏相位门控实时数字化程序和计算机辅助方法，用于对MRT进行密度测定，以获取有关莫沙维林刺激冠状动脉血流储备前后冠状动脉球囊扩张对心肌灌注影响的信息。在22名单支冠状动脉疾病患者中，莫沙维林导致狭窄后MRT显著延长（2.3±1.2秒（平均值±标准差）对2.9±1.1秒，p<0.05），而在成功扩张阻塞性病变后，刺激冠状动脉血流储备后发现MRT显著缩短（2.5±1.2秒对1.9±0.9秒，p<0.05）。与初始扩张前结果相比，扩张后测量的莫沙维林后MRT显著降低（2.9±1.1秒对1.9±0.9秒，p<0.005）；这表明该参数可以很好地描述成功球囊扩张对狭窄后心肌灌注的影响。这些结果表明，在介入性心脏导管检查期间，可以从数字密度测定中获得有关狭窄后心肌灌注的信息。
