泰国女性阴道微生物群的特征分析。
Characterization of vaginal microbiota in Thai women.
作者信息
Sirichoat Auttawit, Buppasiri Pranom, Engchanil Chulapan, Namwat Wises, Faksri Kiatichai, Sankuntaw Nipaporn, Pasomsub Ekawat, Chantratita Wasun, Lulitanond Viraphong
机构信息
Department of Microbiology and Research and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Department of Obstetrics and Gynecology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
出版信息
PeerJ. 2018 Nov 21;6:e5977. doi: 10.7717/peerj.5977. eCollection 2018.
BACKGROUND
The vaginal microbiota (VMB) plays a key role in women's reproductive health. VMB composition varies with ethnicity, making it necessary to characterize the VMB of the target population before interventions to maintain and/or improve the vaginal health are undertaken. Information on the VMB of Thai women is currently unavailable. We therefore characterized the VMB in normal Thai women.
METHODS
Vaginal samples derived from 25 Thai women were subjected to 16S rRNA gene next-generation sequencing (NGS) on the Ion Torrent PGM platform.
RESULTS
Two groups of VMB were detected, lactobacilli-dominated (LD) and non-lactobacilli dominated (NLD) groups. was the most common species found in the LD group while followed by and were commonly found in the NLD group.
CONCLUSIONS
The VMB patterns present in normal Thai women is essential information to further determine the factors associated with VMB patterns in vaginal health and disease and to develop proper management of reproductive health of Thai women.
背景
阴道微生物群（VMB）在女性生殖健康中起关键作用。VMB的组成因种族而异，因此在采取维持和/或改善阴道健康的干预措施之前，有必要对目标人群的VMB进行特征描述。目前尚无泰国女性VMB的相关信息。因此，我们对正常泰国女性的VMB进行了特征描述。
方法
从25名泰国女性采集的阴道样本在Ion Torrent PGM平台上进行16S rRNA基因下一代测序（NGS）。
结果
检测到两组VMB，即以乳酸杆菌为主的（LD）组和非乳酸杆菌为主的（NLD）组。 是LD组中最常见的物种，而 其次是 和 是NLD组中常见的物种。
结论
正常泰国女性中存在的VMB模式是进一步确定与阴道健康和疾病中VMB模式相关因素以及制定泰国女性生殖健康适当管理方法的重要信息。
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