[快速痴呆评定系统在临床实践中的可行性：一项多中心前瞻性验证研究的结果]

[The feasibility of using Quick Dementia Rating System in clinical practice: results of a multi-center prospective validation study].

作者信息

Levin O S, Vasenina E E, Sonin A G, Tayupova G N, Zatsepina O E, Ostapenko T N

机构信息

Russian Medical Academy of Continuous Professional Education, Moscow, Russia.

Project MEMINI.

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(10):40-47. doi: 10.17116/jnevro201811811140.

DOI:10.17116/jnevro201811811140

PMID:30499495

Abstract

AIM

To determine the sensitivity and specificity of the Quick Dementia Rating System (QDRS), a 10-item questionnaire for the assessment of cognitive, behavioral, and functional impairments, in the Russian population.

MATERIAL AND METHODS

The authors examined 2357 patients,1479 female (63%) and 878 male (37%), with subjective cognitive impairment (SCI), mild cognitive impairment (MCI) or dementia. Their average age was 73,1±9,7. All patients were assessed using QDRS and MMSE on baseline visits and reassessed after 1, 3, and 6 months.

RESULTS

The sensitivity and specificity of QDRS were 79,2% and 81,2%, respectively, at cut-interval of more than 7 points. There was a strong inverse correlation between QDRS and MMSE indicators (r=-0,740). QDRS was the most sensitive for the detection of severe dementia (sensitivity of 78,2% and specificity of 85,2%), while for mild and moderate dementia the sensitivity was high (79,4% and 81,6%) and specificity was low (56,6% and 61,9%, respectively). The sensitivity and specificity of separate subtests were variable.

CONCLUSION

The QDRS sensitivity and specificity allow recommending it for clinical practice. The questionnaire is the most sensitive to detect more severe cognitive impairment.

摘要

目的

确定快速痴呆评定系统（QDRS）在俄罗斯人群中的敏感性和特异性。QDRS是一份包含10个条目的问卷，用于评估认知、行为和功能障碍。

材料与方法

作者对2357例主观认知障碍（SCI）、轻度认知障碍（MCI）或痴呆患者进行了检查，其中女性1479例（63%），男性878例（37%）。他们的平均年龄为73.1±9.7岁。所有患者在基线访视时使用QDRS和简易精神状态检查表（MMSE）进行评估，并在1、3和6个月后重新评估。

结果

在截断值大于7分的情况下，QDRS的敏感性和特异性分别为79.2%和81.2%。QDRS与MMSE指标之间存在很强的负相关（r=-0.740）。QDRS对重度痴呆的检测最为敏感（敏感性为78.2%，特异性为85.2%），而对轻度和中度痴呆的敏感性较高（分别为79.4%和81.6%），但特异性较低（分别为56.6%和61.9%）。各个子测试的敏感性和特异性各不相同。