Stem Cell Therapy Unit, Jesús Usón Minimally Invasive Surgery Centre, Ctra. N-521, km 41.8, 10071 Cáceres, Spain.
Stem Cell Therapy Unit, Jesús Usón Minimally Invasive Surgery Centre, Ctra. N-521, km 41.8, 10071 Cáceres, Spain; CIBER de Enfermedades Cardiovasculares, Avenida Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029 Madrid, Spain.
Acta Biomater. 2019 Feb;85:60-74. doi: 10.1016/j.actbio.2018.11.042. Epub 2018 Nov 27.
Surgical meshes are frequently used for the treatment of abdominal hernias, pelvic organ prolapse, and stress urinary incontinence. Though these meshes are designed for tissue reinforcement, many complications have been reported. Both differentiated cell- and mesenchymal stem cell-based therapies have become attractive tools to improve their biocompatibility and tissue integration, minimizing adverse inflammatory reactions. However, current studies are highly heterogeneous, making it difficult to establish comparisons between cell types or cell coating methodologies. Moreover, only a few studies have been performed in clinically relevant animal models, leading to contradictory results. Finally, a thorough understanding of the biological mechanisms of mesenchymal stem cells in the context of foreign body reaction is lacking. This review aims to summarize in vitro and in vivo studies involving the use of differentiated and mesenchymal stem cells in combination with surgical meshes. According to preclinical and clinical studies and considering the therapeutic potential of mesenchymal stem cells, it is expected that these cells will become valuable tools in the treatment of pathologies requiring tissue reinforcement. STATEMENT OF SIGNIFICANCE: The implantation of surgical meshes is the standard procedure to reinforce tissue defects such as hernias. However, an adverse inflammatory response secondary to this implantation is frequently observed, leading to a strong discomfort and chronic pain in the patients. In many cases, an additional surgical intervention is needed to remove the mesh. Both differentiated cell- and stem cell-based therapies have become attractive tools to improve biocompatibility and tissue integration, minimizing adverse inflammatory reactions. However, current studies are incredibly heterogeneous and it is difficult to establish a comparison between cell types or cell coating methodologies. This review aims to summarize in vitro and in vivo studies where differentiated and stem cells have been combined with surgical meshes.
外科网片常用于治疗腹部疝、盆腔器官脱垂和压力性尿失禁。尽管这些网片是为组织增强而设计的，但已经报道了许多并发症。基于分化细胞和间充质干细胞的治疗方法已成为提高其生物相容性和组织整合的有吸引力的工具，最大限度地减少不良炎症反应。然而，目前的研究高度异质，使得难以在细胞类型或细胞涂层方法之间进行比较。此外，只有少数研究在临床相关的动物模型中进行，导致结果相互矛盾。最后，对外来体反应中间充质干细胞的生物学机制缺乏深入了解。本综述旨在总结涉及使用分化细胞和间充质干细胞与外科网片联合使用的体外和体内研究。根据临床前和临床研究，并考虑间充质干细胞的治疗潜力，预计这些细胞将成为需要组织增强的病理治疗的有价值的工具。
外科网片的植入是强化组织缺陷（如疝）的标准程序。然而，这种植入引起的不良反应炎症反应经常发生，导致患者强烈不适和慢性疼痛。在许多情况下，需要进行额外的手术干预来移除网片。基于分化细胞和干细胞的治疗方法已成为提高生物相容性和组织整合的有吸引力的工具，最大限度地减少不良炎症反应。然而，目前的研究非常异质，难以在细胞类型或细胞涂层方法之间进行比较。本综述旨在总结涉及使用分化细胞和干细胞与外科网片联合使用的体外和体内研究。
