Department of Pediatrics, Holtz Children's Hospital, University of Miami Miller School of Medicine/Jackson Memorial Medical Center, 1611 NW 12th Ave, Miami, FL 33136, USA.
Department of Pediatric Gastroenterology, Hepatology and Nutrition, University of Miami Miller School of Medicine, 1601 NW 12th Ave, Miami, FL 33137, USA.
Nutrients. 2018 Nov 29;10(12):1835. doi: 10.3390/nu10121835.
Disaccharidase deficiencies are reportedly underdiagnosed in pediatric populations. Though typically thought to cause diarrheal disease, they can also be a cause of abdominal pain and dyspepsia, and patients diagnosed with these functional disorders may actually have associated enzyme deficiencies. While the effects of lactose deficiency have been widely studied, sucrase, maltase, and isomaltase are less frequently considered when approaching a patient with an apparent functional abdominal pain disorder. This review seeks to provide an up-to-date narrative on the current scientific literature on the possible role of sucrase, maltase, and isomaltase deficiency in pediatric functional gastrointestinal disorders.
据报道，小儿人群中的双糖酶缺乏症诊断不足。尽管这些酶通常被认为会导致腹泻病，但它们也可能是腹痛和消化不良的原因，而被诊断为这些功能性疾病的患者实际上可能存在相关的酶缺乏。虽然乳糖缺乏的影响已被广泛研究，但在治疗表现出明显功能性腹痛障碍的患者时，蔗糖酶、麦芽糖酶和异麦芽糖酶往往较少被考虑。本综述旨在提供关于蔗糖酶、麦芽糖酶和异麦芽糖酶缺乏在小儿功能性胃肠疾病中的可能作用的最新科学文献综述。
