Institute of Chemistry, University of Silesia, Szkolna 9, 40-006 Katowice, Poland.
Department of Physical Pharmacy, Faculty of Pharmacy, Medical University of Silesia, Jagiellonska 4, 41-200 Sosnowiec, Poland.
J Nanosci Nanotechnol. 2019 May 1;19(5):2489-2492. doi: 10.1166/jnn.2019.15855.
Chemically functionalized graphene oxides could be used as novel drug carriers. Covalent alterations of graphene oxides lead to surface changes via formation of chemical bonding while non-covalent ones involve van der Waals forces, hydrogen bonding, and - stacking interactions. Covalent modifications appear to be superior as they can yield compounds with desired properties and carriers prepared by other methods are less stable. Synthesis of graphene oxide-iminodiacetic acid and graphene oxide-glycine involves nucleophilic substitution of graphene oxide nanoparticles with iminodiacetic acid or glycine. As the first step, iminodiacetic acid or glycine were transformed into iminodiacetic acid or glycine methyl ester hydrochlorides, respectively, for C-terminus protection. The obtained product, activated , was then used to form amide bonds between graphene oxide and iminodiacetic acid or glycine.
经化学功能化的氧化石墨烯可用作新型药物载体。通过形成化学键，对氧化石墨烯进行共价修饰可导致表面发生变化，而非共价修饰则涉及范德华力、氢键和π-π 堆积相互作用。共价修饰似乎更优越，因为它们可以产生具有所需性质的化合物，而通过其他方法制备的载体则不太稳定。氧化石墨烯-亚氨基二乙酸和氧化石墨烯-甘氨酸的合成涉及用亚氨基二乙酸或甘氨酸对氧化石墨烯纳米粒子进行亲核取代。作为第一步，分别将亚氨基二乙酸或甘氨酸转化为亚氨基二乙酸或甘氨酸甲酯盐酸盐，以保护 C 末端。然后，所得的活化产物被用于在氧化石墨烯和亚氨基二乙酸或甘氨酸之间形成酰胺键。
