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使用基于石墨烯的材料和碳纳米管的药物递送纳米系统的进展

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes.

作者信息

Jampilek Josef, Kralova Katarina

机构信息

Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska Cesta 9, 845 10 Bratislava, Slovakia.

Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacky University, Slechtitelu 27, 783 71 Olomouc, Czech Republic.

出版信息

Materials (Basel). 2021 Feb 24;14(5):1059. doi: 10.3390/ma14051059.

Abstract

Carbon is one of the most abundant elements on Earth. In addition to the well-known crystallographic modifications such as graphite and diamond, other allotropic carbon modifications such as graphene-based nanomaterials and carbon nanotubes have recently come to the fore. These carbon nanomaterials can be designed to help deliver or target drugs more efficiently and to innovate therapeutic approaches, especially for cancer treatment, but also for the development of new diagnostic agents for malignancies and are expected to help combine molecular imaging for diagnosis with therapies. This paper summarizes the latest designed drug delivery nanosystems based on graphene, graphene quantum dots, graphene oxide, reduced graphene oxide and carbon nanotubes, mainly for anticancer therapy.

摘要

碳是地球上最丰富的元素之一。除了众所周知的晶体结构变体,如石墨和金刚石外,其他碳的同素异形体变体,如基于石墨烯的纳米材料和碳纳米管,最近也备受关注。这些碳纳米材料可以被设计用来更有效地递送或靶向药物,并创新治疗方法,特别是用于癌症治疗,也用于开发针对恶性肿瘤的新型诊断试剂,有望将诊断用的分子成像与治疗相结合。本文总结了基于石墨烯、石墨烯量子点、氧化石墨烯、还原氧化石墨烯和碳纳米管的最新设计的药物递送纳米系统,主要用于抗癌治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e7/7956197/06c8abba40ad/materials-14-01059-g001.jpg

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