Basripuzi N Hayyan, Salisi M Shahrom, Isa N Mahiza Md, Busin Valentina, Cairns Callum, Jenvey Caitlin, Stear Michael J
Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom; Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Locked Bag 36, Pengkalan Chepa, 16100 Kota Bharu, Kelantan Darul Naim, Malaysia.
Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom; Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia.
Vet Parasitol. 2018 Dec 15;264:18-25. doi: 10.1016/j.vetpar.2018.10.014. Epub 2018 Oct 22.
Gastrointestinal nematode infection is one of the major diseases affecting small ruminants. Although some breeds of goats are quite resistant, many breeds of goats are relatively susceptible. This study used a combined parasitological, immunological, bioinformatic and statistical approach to examine the role of goat IgA and eosinophils in protection against Teladorsagia circumcincta. Molecular modelling suggested that the transmembrane domain of the high affinity IgA receptor was dysfunctional in goats. Statistical analyses failed to find any association in naturally infected goats between high IgA or eosinophil responses and low faecal egg counts. Together these results indicate that IgA and eosinophil responses against T. circumcincta are less effective in goats than sheep.
胃肠道线虫感染是影响小反刍动物的主要疾病之一。虽然某些品种的山羊具有较强的抵抗力，但许多品种的山羊相对易感。本研究采用寄生虫学、免疫学、生物信息学和统计学相结合的方法，研究山羊IgA和嗜酸性粒细胞在抵抗环形泰勒虫感染中的作用。分子建模表明，高亲和力IgA受体的跨膜结构域在山羊中功能失调。统计分析未能在自然感染的山羊中发现高IgA或嗜酸性粒细胞反应与低粪便虫卵计数之间存在任何关联。这些结果共同表明，山羊针对环形泰勒虫的IgA和嗜酸性粒细胞反应不如绵羊有效。
