超声响应型载药液滴：综述
Ultrasound-responsive droplets for therapy: A review.
机构信息
Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada.
Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada.
出版信息
J Control Release. 2019 Jan 10;293:144-154. doi: 10.1016/j.jconrel.2018.11.028. Epub 2018 Nov 29.
Abstract
The last two decades have seen the development of acoustically activated droplets, also known as phase-change emulsions, from a diagnostic tool to a therapeutic agent. Through bubble effects and triggered drug release, these superheated agents have found potential applications from oncology to neuromodulation. The aim of this review is to summarise the key developments in therapeutic droplet design and use, to discuss the current challenges slowing clinical translation, and to highlight the new frontiers progressing towards clinical implementation. The literature is summarised by addressing the droplet design criteria and by carrying out a multiparametric study of a range of droplet formulations and their associated vaporisation thresholds.
摘要
在过去的二十年中，声控液滴（也称为相变型乳液）已从诊断工具发展为治疗剂。通过气泡效应和触发药物释放，这些过热试剂在肿瘤学和神经调节等领域有了潜在的应用。本文的目的是总结治疗性液滴设计和应用的关键进展，讨论阻碍临床转化的当前挑战，并强调朝着临床应用推进的新前沿。通过解决液滴设计标准，并对一系列液滴配方及其相关蒸汽压阈值进行多参数研究，对文献进行了总结。
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