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表皮生长因子样结构域多重 7（EGFL7）：在胆管癌中的表达及其对胆管上皮细胞生长的可能影响

Epidermal growth factor-like domain multiple 7 (EGFL7): Expression and possible effect on biliary epithelium growth in cholangiocarcinoma.

作者信息

Mammola Caterina L, Vetuschi Antonella, Pannarale Luigi, Sferra Roberta, Mancinelli Romina

机构信息

Sapienza University of Rome, Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences.

出版信息

Eur J Histochem. 2018 Nov 30;62(4):2971. doi: 10.4081/ejh.2018.2971.

DOI:10.4081/ejh.2018.2971
PMID:30504933
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6291760/
Abstract

Cholangiocarcinoma (CCA) is an aggressive biliary tract malignancy with limited treatment options and low survival rates. The intrahepatic subtype comprises two forms: mucin-iCCA and mixed-iCCA. Epidermal growth factor-like domain multiple (EGFL7) is overexpressed in less differentiated liver tumors. The aim of this study was to assess the presence of EGFL7 due to its possible role in the growth of CCA. Hematoxylin and Eosin and periodic acid-Schiff staining were used to evaluate the morphological aspects and glycogen deposition. Immunohistochemistry and immunofluorescence were performed to identify the presence of EGFL7 both in tumor sections ex vivo and in appropriate cell lines in culture. We found that EGFL7 is expressed in malignant cholangiocytes of mixed-iCCA and absent in mucin-iCCA. In conclusion the expression of EGFL7 might be useful in the classification of CCA subtypes.

摘要

胆管癌（CCA）是一种侵袭性胆道恶性肿瘤，治疗选择有限且生存率低。肝内亚型包括两种形式：黏液性肝内胆管癌（mucin-iCCA）和混合型肝内胆管癌（mixed-iCCA）。表皮生长因子样结构域多重蛋白（EGFL7）在分化程度较低的肝肿瘤中过度表达。本研究的目的是评估EGFL7的存在情况，因为其可能在CCA生长中发挥作用。采用苏木精-伊红染色和过碘酸-希夫染色来评估形态学特征和糖原沉积。进行免疫组织化学和免疫荧光检测，以确定EGFL7在体外肿瘤切片和培养的合适细胞系中的存在情况。我们发现EGFL7在混合型肝内胆管癌的恶性胆管细胞中表达，而在黏液性肝内胆管癌中不存在。总之，EGFL7的表达可能有助于CCA亚型的分类。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4860/6291760/f02a65253506/ejh-62-4-2971-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4860/6291760/d6c40f38682e/ejh-62-4-2971-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4860/6291760/192765cf34ed/ejh-62-4-2971-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4860/6291760/f02a65253506/ejh-62-4-2971-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4860/6291760/d6c40f38682e/ejh-62-4-2971-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4860/6291760/192765cf34ed/ejh-62-4-2971-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4860/6291760/f02a65253506/ejh-62-4-2971-g003.jpg

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