Kanabar D, Randhawa M, Clayton P
Department of Paediatrics, Guy's Hospital, London, UK.
J Hum Nutr Diet. 2001 Oct;14(5):359-63. doi: 10.1046/j.1365-277x.2001.00304.x.
Transient lactose intolerance has been identified as a possible causative factor in infant colic. A double-blind randomised placebo-controlled crossover study to investigate this has been undertaken in 53 babies with symptoms of colic. Pre-incubation of the feed with lactase resulted in breath hydrogen levels and total crying time which were both at least 45% lower than figures with placebo treatment, in 26% of the full trial group (95% confidence interval 12.9% to 44.4%), and in 38% of compliers (95% confidence interval 18.8% to 59.4%). The remainder did not respond to the same extent. These findings suggest that infant colic may have a multiple aetiology, and that in a significant number of cases the immediate cause is transient lactose intolerance, in which cases pretreatment of feeds with lactase can result in considerable symptomatic benefits.
短暂性乳糖不耐受已被确认为婴儿腹绞痛的一个可能致病因素。一项针对53名有腹绞痛症状婴儿的双盲随机安慰剂对照交叉研究已开展，旨在对此进行调查。在整个试验组的26%（95%置信区间为12.9%至44.4%）以及依从者的38%（95%置信区间为18.8%至59.4%）中，用乳糖酶对喂养食物进行预孵育后，呼气中氢气水平和总哭闹时间均比安慰剂治疗时的数值至少低45%。其余婴儿的反应程度则不同。这些发现表明，婴儿腹绞痛可能有多种病因，并且在相当多的病例中，直接原因是短暂性乳糖不耐受，在这些病例中，用乳糖酶对喂养食物进行预处理可带来显著的症状改善。
