在上海高危糖尿病筛查（SHiDS）研究中，咖啡摄入量与胰岛素分泌呈正相关。
Coffee consumption is positively related to insulin secretion in the Shanghai High-Risk Diabetic Screen (SHiDS) Study.
作者信息
Gao Fei, Zhang Yinan, Ge Sheng, Lu Huijuan, Chen Ruihua, Fang Pingyan, Shen Yixie, Wang Congrong, Jia Weiping
机构信息
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes, Shanghai, China.
2Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Key Laboratory of Diabetes, The Metabolic Diseases Biobank, Center for Translational Medicine, Shanghai, China.
出版信息
Nutr Metab (Lond). 2018 Nov 27;15:84. doi: 10.1186/s12986-018-0321-8. eCollection 2018.
BACKGROUND
It has been proved that coffee consumption was associated with a lower risk of type 2 diabetes mellitus. But the benefit effect of coffee on hyperglycemia in Chinese population was largely unknown. Besides, the relationship of coffee intake and diabetic pathogenesis was still unclear.
METHODS
The study population was selected from the Shanghai High-Risk Diabetic Screen (SHiDS) project. A total of 1328 individuals over 18 years of age who have the information of coffee intake were enrolled in the study from 2012 to 2016. Each participant finished a five-point 75 g oral glucose tolerance test and finished a standard questionnaire. Insulin resistance was evaluated by HOMA-IR and insulin secretion was evaluated by HOMA-β, Stumvoll first phase and second phase indexes.
RESULTS
Coffee consumption group had lower plasma glucose levels at 2-h and 3-h and higher insulin levels at fasting, 30-min and 1-h during OGTT after adjustment with age, fat%, BMI, waist, tea intake, smoking habit, alcohol intake, diabetes family history and educational status (P for PG2h = 0.002; P for PG3h = 0.010; P for FIN = 0.010; P for IN30min = 0.001; P for IN1h = 0.002). Both HOMA-β and Stumvoll formula indexes were positively related to coffee consumption (P for HOMA-β = 0.033; P for Stumvoll first phase = 0.003; P for Stumvoll second phase = 0.001). Logistic regression analysis further confirmed that coffee intake was independently associated with higher levels of HOMA-β and Stumvoll insulin secretion indexes [OR (95% CI) for HOMA-β = 2.270 (1.456-3.538); OR (95% CI) for Stumvoll first phase = 2.071 (1.352-3.173); OR (95% CI) for Stumvoll second phase = 1.914 (1.260-2.906)].
CONCLUSIONS
Coffee intake is independently and positively related to pancreatic beta cell function in a large high-risk diabetic Chinese population.
背景
已有证据表明，饮用咖啡与降低2型糖尿病风险相关。但咖啡对中国人群高血糖的有益作用在很大程度上尚不清楚。此外，咖啡摄入量与糖尿病发病机制之间的关系仍不明确。
方法
研究人群选自上海糖尿病高危人群筛查（SHiDS）项目。2012年至2016年，共有1328名18岁以上且有咖啡摄入量信息的个体纳入研究。每位参与者均完成了五点75克口服葡萄糖耐量试验，并填写了一份标准问卷。采用稳态模型评估胰岛素抵抗（HOMA-IR），采用HOMA-β、Stumvoll第一阶段和第二阶段指标评估胰岛素分泌。
结果
在校正年龄、脂肪百分比、体重指数、腰围、茶摄入量、吸烟习惯、饮酒量、糖尿病家族史和教育程度后，咖啡饮用组在口服葡萄糖耐量试验2小时和3小时时的血糖水平较低，在空腹、30分钟和1小时时的胰岛素水平较高（2小时血糖P = 0.002；3小时血糖P = 0.010；空腹胰岛素P = 0.010；30分钟胰岛素P = 0.001；1小时胰岛素P = 0.002）。HOMA-β和Stumvoll公式指标均与咖啡摄入量呈正相关（HOMA-β P = 0.033；Stumvoll第一阶段P = 0.003；Stumvoll第二阶段P = 0.001）。Logistic回归分析进一步证实，咖啡摄入量与较高水平的HOMA-β和Stumvoll胰岛素分泌指标独立相关[HOMA-β的比值比（95%可信区间）= 2.270（1.456 - 3.538）；Stumvoll第一阶段的比值比（95%可信区间）= 2.071（1.352 - 3.173）；Stumvoll第二阶段的比值比（95%可信区间）= 1.914（1.260 - 2.906）]。
结论
在大量中国糖尿病高危人群中，咖啡摄入量与胰岛β细胞功能独立正相关。
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