Corresponding author: Frank B. Hu,
Diabetes Care. 2014 Feb;37(2):569-86. doi: 10.2337/dc13-1203.
Previous meta-analyses identified an inverse association of coffee consumption with the risk of type 2 diabetes. However, an updated meta-analysis is needed because new studies comparing the trends of association for caffeinated and decaffeinated coffee have since been published.
PubMed and Embase were searched for cohort or nested case-control studies that assessed the relationship of coffee consumption and risk of type 2 diabetes from 1966 to February 2013. A restricted cubic spline random-effects model was used.
Twenty-eight prospective studies were included in the analysis, with 1,109,272 study participants and 45,335 cases of type 2 diabetes. The follow-up duration ranged from 10 months to 20 years. Compared with no or rare coffee consumption, the relative risk (RR; 95% CI) for diabetes was 0.92 (0.90-0.94), 0.85 (0.82-0.88), 0.79 (0.75-0.83), 0.75 (0.71-0.80), 0.71 (0.65-0.76), and 0.67 (0.61-0.74) for 1-6 cups/day, respectively. The RR of diabetes for a 1 cup/day increase was 0.91 (0.89-0.94) for caffeinated coffee consumption and 0.94 (0.91-0.98) for decaffeinated coffee consumption (P for difference = 0.17).
Coffee consumption was inversely associated with the risk of type 2 diabetes in a dose-response manner. Both caffeinated and decaffeinated coffee was associated with reduced diabetes risk.
先前的荟萃分析表明，咖啡饮用与 2 型糖尿病的风险呈负相关。然而，由于此后发表了比较含因咖啡和脱因咖啡关联趋势的新研究，因此需要进行更新的荟萃分析。
检索了 1966 年至 2013 年 2 月间评估咖啡饮用与 2 型糖尿病风险关系的队列或巢式病例对照研究的 PubMed 和 Embase 数据库。采用限制立方样条随机效应模型。
共纳入 28 项前瞻性研究，共 1109272 名研究参与者和 45335 例 2 型糖尿病病例。随访时间从 10 个月到 20 年不等。与不饮用或很少饮用咖啡相比，每天饮用 1-6 杯咖啡时，糖尿病的相对风险（RR；95%CI）分别为 0.92（0.90-0.94）、0.85（0.82-0.88）、0.79（0.75-0.83）、0.75（0.71-0.80）、0.71（0.65-0.76）和 0.67（0.61-0.74）；每天增加 1 杯时，RR 分别为 0.91（0.89-0.94）和 0.94（0.91-0.98）（P 差值=0.17）。
咖啡饮用量与 2 型糖尿病风险呈负相关，呈剂量反应关系。含因和脱因咖啡均与降低糖尿病风险相关。
