Zhang Chanqiong, Huang Chongan, Zheng Xiang, Pan Dan
Department of Pathology, Wenzhou People's Hospital, The third Clinical Institute Affiliated to Wenzhou Medical University, 299 Guan Rd. Ouhai district, Wenzhou, Zhejiang, China.
2Department of Spine Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Infect Agent Cancer. 2018 Nov 26;13:37. doi: 10.1186/s13027-018-0211-8. eCollection 2018.
Human papillomavirus (HPV) is associated with an increased risk of cervical cancer. Using a vaccine to prevent HPV infections could be a cost-effective strategy to decrease the incidence of cervical cancer. Learning about the characteristics of CIN patients with HPV infection in Wenzhou is a key step in guiding the use of HPV vaccines and screening for cervical cancer.
We undertook a retrospective analysis including 2612 women who were treated in the Department of Gynecology and Obstetrics from Jan 2016 to Nov 2017. All of the patients were examined by HPV testing and histology.
The prevalence of HR-HPV among women with cervical intraepithelial lesions aged 65-69 years (38.8%) was significantly higher than that of the other age groups. The percentage of patients diagnosed with HPV-positive HSIL progressively increased with age to a maximum of 18.0% in the group of 40 to 44 years of age. HPV 16, 52, and 58 were the three most dominant genotypes among these women, and single infections (950, 73.3%) were more common than multiple infections (346, 26.7%). Compared to cervicitis, the odds ratios (ORs) for LSIL associated with HPV 33, 52, 16 and HPV 58 infection were 5.98, 3.91, 3.65, 3.65, and 3.188, respectively; for HSIL associated with HPV 16, 33, 58 and HPV 31 were 9.30, 7.68, 5.97, and 4.21, respectively. In LSIL, the frequencies of HR-HPV 52,16,58,18 were 19.3,18.2,10.9, and 7.8%, respectively.
Our study provides important data about the HPV genotype distribution and its correlation with cervical intraepithelial lesions in the Wenzhou population.
人乳头瘤病毒（HPV）与宫颈癌风险增加相关。使用疫苗预防HPV感染可能是降低宫颈癌发病率的一种具有成本效益的策略。了解温州地区HPV感染的宫颈上皮内瘤变（CIN）患者的特征是指导HPV疫苗使用和宫颈癌筛查的关键一步。
我们进行了一项回顾性分析，纳入了2016年1月至2017年11月在妇产科接受治疗的2612名女性。所有患者均接受HPV检测和组织学检查。
65 - 69岁宫颈上皮内病变女性中高危型HPV（HR-HPV）的患病率（38.8%）显著高于其他年龄组。诊断为HPV阳性的高级别鳞状上皮内病变（HSIL）患者的百分比随年龄逐渐增加，在40至44岁年龄组中最高达18.0%。HPV 16、52和58是这些女性中最主要的三种基因型，单一感染（950例，73.3%）比多重感染（346例，26.7%）更常见。与宫颈炎相比，与HPV 33、52、16和HPV 58感染相关的低级别鳞状上皮内病变（LSIL）的比值比（OR）分别为5.98、3.91、3.65、3.65和3.188；与HPV 16、33、58和HPV 31相关的HSIL的OR分别为9.30、7.68、5.97和4.21。在LSIL中，HR-HPV 52、16、58、18的频率分别为19.3%、18.2%、10.9%和7.8%。
我们的研究提供了有关温州人群中HPV基因型分布及其与宫颈上皮内病变相关性的重要数据。
