精油：从预防到治疗皮肤癌。

Essential oils: from prevention to treatment of skin cancer.

机构信息

School of BioSciences and Technology, Vellore Institute of Technology, Vellore 632 014, India.

Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600 036, India.

出版信息

Drug Discov Today. 2019 Feb;24(2):644-655. doi: 10.1016/j.drudis.2018.11.020. Epub 2018 Nov 30.

DOI:10.1016/j.drudis.2018.11.020

PMID:30508640

Abstract

The increasing incidence of cutaneous malignancies signifies the need for multiple treatment options. Several available reviews have emphasized the potential role of various botanical extracts and naturally occurring compounds as anti-skin-cancer agents. Few studies relate to the role of chemoprevention and therapeutic activity of essential oils (EOs) and EO components. The present review summarizes an overview of chemopreventive, anti-melanoma and anti-nonmelanoma activities of EOs from various plants and EO components in in vitro and in vivo models with special emphasis on skin cancer. Also, the mechanisms by which EOs and EO components exert their effects to induce cell death are presented.

摘要

皮肤恶性肿瘤发病率的上升表明需要多种治疗选择。一些现有的综述强调了各种植物提取物和天然存在的化合物作为抗皮肤癌药物的潜在作用。很少有研究涉及精油 (EOs) 和 EO 成分的化学预防和治疗活性。本综述总结了各种植物的 EO 及其 EO 成分在体外和体内模型中预防化学诱发性、抗黑色素瘤和抗非黑色素瘤活性的概述，特别强调了皮肤癌。此外，还介绍了 EO 和 EO 成分发挥作用诱导细胞死亡的机制。