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疾病的生物化学基础。

The biochemical basis of disease.

机构信息

Department of Biomedical Science, University of Westminster, London, U.K.

出版信息

Essays Biochem. 2018 Dec 2;62(5):619-642. doi: 10.1042/EBC20170054. Print 2018 Dec 3.

Abstract

This article gives the reader an insight into the role of biochemistry in some of the current global health and disease problems. It surveys the biochemical causes of disease in an accessible and succinct form while also bringing in aspects of pharmacology, cell biology, pathology and physiology which are closely aligned with biochemistry. The discussion of the selected diseases highlights exciting new developments and illuminates key biochemical pathways and commonalities. The article includes coverage of diabetes, atherosclerosis, cancer, microorganisms and disease, nutrition, liver disease and Alzheimer's disease, but does not attempt to be comprehensive in its coverage of disease, since this is beyond its remit and scope. Consequently there are many fascinating biochemical aspects of diseases, both common and rare, that are not addressed here that can be explored in the further reading cited. Techniques and biochemical procedures for studying disease are not covered in detail here, but these can be found readily in a range of biochemical methods sources.

摘要

本文使读者深入了解生物化学在当前一些全球健康和疾病问题中的作用。它以易于理解和简洁的形式调查了疾病的生化原因,同时还引入了药理学、细胞生物学、病理学和生理学的各个方面,这些都与生物化学密切相关。所选疾病的讨论突出了令人兴奋的新发展,并阐明了关键的生化途径和共性。本文涵盖了糖尿病、动脉粥样硬化、癌症、微生物与疾病、营养、肝病和阿尔茨海默病,但并未试图全面涵盖疾病,因为这超出了其范围。因此,有许多令人着迷的疾病的生化方面,无论是常见的还是罕见的,都没有在这里提到,可以在引用的进一步阅读中探索。本文没有详细介绍研究疾病的技术和生化程序,但可以在一系列生化方法来源中轻松找到这些内容。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16c2/6279435/15a267323eaf/ebc-62-ebc20170054-g1.jpg

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