Sabolović N, Prieur A M, Griscelli C
Scand J Immunol. 1977;6(12):1199-207. doi: 10.1111/j.1365-3083.1977.tb00358.x.
Peripheral blood lymphocytes from 16 patients with juvenile rheumatoid arthritis and 27 age-matched healthy controls have been studied, using several lymphocyte markers: electrophoretic mobility (EM), E-rosettes, immunofluorescence, and refringency. Eight patients (mean age, 6 years) were selected with a typical EM pattern--that is, a decrease in the mean EM of T cells and increase in B versus T-cell ratio. The other group of patients (mean age, 11 years) showed no significant difference when compared with their age-matched controls, with the exception of the positive refringence test. These findings suggest an impairment in the maturation of the immune system in childhood, which in turn may be responsible for the increased susceptibility to disease.
对16例幼年类风湿性关节炎患者及27例年龄匹配的健康对照者的外周血淋巴细胞进行了研究，采用了几种淋巴细胞标志物：电泳迁移率（EM）、E花环、免疫荧光和折光率。选择了8例患者（平均年龄6岁），其具有典型的EM模式，即T细胞平均EM降低，B细胞与T细胞比值增加。另一组患者（平均年龄11岁）与年龄匹配的对照者相比，除折光率试验阳性外，无显著差异。这些发现提示儿童期免疫系统成熟存在损害，这反过来可能是疾病易感性增加的原因。
