Dobloug J H, Chattopadhyay C, Førre O, Høyeraal H M, Natvig J B
Scand J Immunol. 1981;13(4):367-73. doi: 10.1111/j.1365-3083.1981.tb00146.x.
Suppressor cell activity was investigated in peripheral blood lymphocytes from twenty patients with rheumatoid arthritis (RA) and twenty patients with juvenile rheumatoid arthritis (JRA) using a concanavalin A/mixed lymphocyte culture assay. The mean suppression in the RA patients was slightly reduced compared with the suppressor cell activity in adult controls (25 +/- 5% suppression compared with 37 +/- 5%; P less than 0.05, Student's t test), whereas the JRA patients had normal suppressor cell activity (mean 46 +/- 5% versus 43 +/- 5% in healthy children matched for age and sex). The RA patients had normal proportions of T-cell subpopulations, 13.3% T gamma cells and 49.8% T mu cells, compared with 13.8% and 58.0% in controls. The JRA patients, however, had a significantly reduced mean percentage of T gamma cells, 6.6%, compared with 13.8% in healthy children (P less than 0.05, Mann-Whitney U-test). The mean percentage of T mu cells was 53.7%, versus 56.2% in the controls. The relation between suppressor cell activity and suppressor cells enumerated by membrane markers is discussed.
采用刀豆球蛋白A/混合淋巴细胞培养试验，对20例类风湿性关节炎（RA）患者和20例青少年类风湿性关节炎（JRA）患者外周血淋巴细胞中的抑制细胞活性进行了研究。与成年对照组的抑制细胞活性相比，RA患者的平均抑制率略有降低（分别为25±5%和37±5%；P<0.05，Student t检验），而JRA患者的抑制细胞活性正常（年龄和性别匹配的健康儿童平均为46±5%，与之相比为43±5%）。与对照组的13.8%和58.0%相比，RA患者T细胞亚群比例正常，Tγ细胞为13.3%，Tμ细胞为49.8%。然而，JRA患者的Tγ细胞平均百分比显著降低，为6.6%，而健康儿童为13.8%（P<0.05，Mann-Whitney U检验）。Tμ细胞的平均百分比为53.7%，对照组为56.2%。文中讨论了抑制细胞活性与通过膜标记物计数的抑制细胞之间的关系。
