He Jiayi, Zhang Xinmei
Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2018 Feb 25;47(4):419-425. doi: 10.3785/j.issn.1008-9292.2018.08.15.
A large number of studies have shown that the oxidative imbalance is common in patients with endometriosis. Abnormal respiratory chain of mitochondrial, estrogen metabolism imbalance, iron overload, and ectopic foci may increase active oxygen, reduction of antioxidant enzyme and non-enzymatic substances may result in decreased antioxidant level, and the exposure to environmental hazards may further aggravate oxidative imbalance in patients with endometriosis. This article analyzes the oxidative imbalance and its role in the pathogenesis of endometriosis from the aspects of excessive oxide production and decreased antioxidant capacity.
大量研究表明，氧化失衡在子宫内膜异位症患者中很常见。线粒体呼吸链异常、雌激素代谢失衡、铁过载以及异位病灶可能会增加活性氧，抗氧化酶和非酶物质的减少可能导致抗氧化水平降低，而暴露于环境危害因素可能会进一步加重子宫内膜异位症患者的氧化失衡。本文从氧化物产生过多和抗氧化能力降低两个方面分析氧化失衡及其在子宫内膜异位症发病机制中的作用。
