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基于比较基因组学对[物种名称]代谢的见解。 （原文中“sp.”指代不明，推测是某个物种的缩写，这里统一用[物种名称]表示）

Insights Into sp. Metabolism Based on Comparative Genomics.

作者信息

Lima Alex Ranieri Jerônimo, Siqueira Andrei Santos, de Vasconcelos Janaina Mota, Pereira James Siqueira, de Azevedo Juliana Simão Nina, Moraes Pablo Henrique Gonçalves, Aguiar Délia Cristina Figueira, de Lima Clayton Pereira Silva, Vianez-Júnior João Lídio Silva Gonçalves, Nunes Márcio Roberto Teixeira, Xavier Luciana Pereira, Dall'Agnol Leonardo Teixeira, Goncalves Evonnildo Costa

机构信息

Laboratório de Tecnologia Biomolecular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Brazil.

Laboratório de Biodiversidade Molecular, Universidade Federal Rural da Amazônia, Campus de Capanema, Capanema, Brazil.

出版信息

Front Microbiol. 2018 Nov 20;9:2811. doi: 10.3389/fmicb.2018.02811. eCollection 2018.

DOI:10.3389/fmicb.2018.02811
PMID:30515147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6256058/
Abstract

Currently only four genome sequences for spp. are publicly available, and information on the genetic properties of cyanobacteria belonging to this genus is limited. In this study, we report the draft genome of sp. CACIAM 69d, isolated from the reservoir of a hydroelectric dam located in the Amazon ecosystem, from where cyanobacterial genomic data are still scarce. Comparative genomic analysis of revealed the presence of key enzymes in the cyanobacterial central carbon metabolism and how it is well equipped for environmental sulfur and nitrogen acquisition. Additionally, this work covered the analysis of CRISPR-Cas systems, pathways related to biosynthesis of secondary metabolites and assembly of extracellular polymeric substances and their exportation. A -AT PKS gene cluster was identified in two strains, possibly related to the novel toxin Limnothrixin biosynthesis. Overall, the draft genome of sp. CACIAM 69d adds new data to the small genome library and contributes to a growing representativeness of cyanobacterial genomes from the Amazon region. The comparative genomic analysis of made it possible to highlight unique genes for each strain and understand the overall features of their metabolism.

摘要

目前，仅公开了四种 属物种的基因组序列，关于该属蓝藻遗传特性的信息有限。在本研究中，我们报告了从位于亚马逊生态系统的一座水电站大坝水库中分离出的 种CACIAM 69d的基因组草图，该地区的蓝藻基因组数据仍然匮乏。对 的比较基因组分析揭示了蓝藻中心碳代谢中关键酶的存在以及其获取环境中硫和氮的良好能力。此外，这项工作还涵盖了对CRISPR-Cas系统、与次生代谢物生物合成相关的途径以及细胞外聚合物的组装及其输出的分析。在两个菌株中鉴定出了一个 -AT PKS基因簇，可能与新型毒素Limnothrixin的生物合成有关。总体而言， 种CACIAM 69d的基因组草图为小型的 基因组文库增添了新数据，并有助于提高亚马逊地区蓝藻基因组的代表性。对 的比较基因组分析使得突出每个菌株的独特基因并了解其代谢的总体特征成为可能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/8cb686ba9cbf/fmicb-09-02811-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/6965fc416fee/fmicb-09-02811-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/6b33c36a223f/fmicb-09-02811-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/f4a7673e4a26/fmicb-09-02811-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/156d45c15381/fmicb-09-02811-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/3c9843b70f7f/fmicb-09-02811-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/65496be34845/fmicb-09-02811-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/38703e1f2dff/fmicb-09-02811-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/177f3868ef4d/fmicb-09-02811-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/fb9cbb2e5acf/fmicb-09-02811-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/8cb686ba9cbf/fmicb-09-02811-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/6965fc416fee/fmicb-09-02811-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/6b33c36a223f/fmicb-09-02811-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/f4a7673e4a26/fmicb-09-02811-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/156d45c15381/fmicb-09-02811-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/3c9843b70f7f/fmicb-09-02811-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/65496be34845/fmicb-09-02811-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/38703e1f2dff/fmicb-09-02811-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/177f3868ef4d/fmicb-09-02811-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/fb9cbb2e5acf/fmicb-09-02811-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d011/6256058/8cb686ba9cbf/fmicb-09-02811-g010.jpg

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